「エチノピンA, B　〜新規骨格セスキテルペノイド〜」　2009.5　

モロッコ産キク科ヒゴタイ属植物の根から、新規骨格を有するセスキテルペノイド2種を単離しました。その7/5/5/3員環骨格をエキノパン骨格と名付け、合成研究を始めました。

共同研究先：故・史清文先生（中国・河北医科大学）実験者：田中功二、長島優太
118. "Echinopines A and B: Sesquiterpenoids Possessing an Unprecedented Skeleton from Echinops spinosus"
　　M. Dong, B. Cong, S.-H. Yu, F. Sauriol, C.-H. Huo, Q.-W. Shi,Y.-C. Gu, L. O. Zamir, H. Kiyota, Org. Lett., 10, 701-704 (2008).

T-78. 11-Hydroxyisocom-2-en-5-one, a A New Sesquiterpenoid from Echinops spinosissimus
Zhi-Yu Ni, Yuta Nagashima, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Chem. Nat. Compds., 49(4), 632-634 (2013).

キク科ノコギリソウ属Achillea millefolium、オグルマ属Inula helenium、ヨモギ属Artemisia frigida、ブクリョウサイ属Dichrocephala integrifolia（茯苓菜）
等の花から、新規セスキテルペノイドやフラボノイドを単離し、構造変換や代謝研究を行いました。

共同研究先：故・史清文先生（中国・河北医科大学）
T-26. Chemical Constituents of the Plants in Genus Achillea [REVIEW]
Yong-Ming Zhao, Man-Li Zhang, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 3, 1163-1180 (2006).

T-23. Chemical Constituents of the Plants in Genus Inula [REVIEW]
Yong-Ming Zhao, Man-Li Zhang, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 3, 371-384 (2006).

T-100. Bruceine B-induced Apoptosis of Lung Cancer Cells NCI-H292 through Endoplasmic Reticulum Stress, Death Receptor and Mitochondria-dependent Signaling Pathways
Wen-Zhe Li, Feng Yu, Chuan Wang, Qing-wen Shi, Mei Dong, Zhi- Yu Ni, Mao-Chang Ji, Hiromasa Kiyota, Curr. Top. Phytochemistry, 18, 11-18 (2023).

T-97. Millifolide A, a Dimeric Ether of Degraded Sesquiterpene Lactones, Inhibited the Proliferation of Human Lung Cancer Cell Line A549
Pan-Pan Yu, Feng Yu, Wen-Zhe Li, Si-Ming Wang, Chuan Wang, Mei Dong, Zhi-Yu Ni, Yong Li, Qing-Wen Shi, Hiromasa Kiyota, Nat. Prod. Chem., 36(11), 2875-2877 (2022), 10.1080/14786419.2021.1922906.

T-92. Study on the Metabolites of Isoalantolactone in vivo and in vitro by Ultra Performance Liquid Chromatography Combined with Triple TOF Mass Spectrometry
Dong-Gui Yao, Yu-Fang, Wang, Chang-Hong Huo, Yi-Bing Wu, Man-Li Zhang, Li-Geng Li, Qing-Wen Shi, Hiromasa Kiyota, Xiao-Wei Shi, Food Chem., 214, 328-338 (2017), 10.1016/j.foodchem.2016.07.100.

T-91. Identification of in vivo and in vitro Metabolites of Alantolactone by UPLC-TOF-MS/MS
Dong-Gui Yao, Zhe Li, Chang-Hong Huo, Yu-Fang, Wang, Yi-Bing Wu, Man-Li Zhang, Li-Geng Li, Qing-Wen Shi, Hiromasa Kiyota, Xiao-Wei Shi, J. Chromatogr. B, 1033, 250-260 (2016), 10.1016/j.jchromb.2016.08.034.

T-83. Structural Modification of Isoalantolactone and Biological Activity Against the Hepatoma Cell Line
Rui-Xia Guo, Li-Geng Li, Man-Li Zhang, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Heterocycl. Commun., 20(2), 117-121 (2014), 10.1515/hc-2013-0220.

T-81. A New Eudesmane Sesquiterpene from Dichrocephala integrifolia
Fang Qin, Yi-Bing Wu, Rui-Xia Guo, Mei Dong, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Nat. Prod. Commun., 9(2), 149-150 (2014).

T-80. Arteminal, a New Eudesmane Sesquiterpenolide Isolated from Artemisia frigida
Cun-Fang Li, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong, Chem. Nat. Cmpd., 49(5), 872-874 (2013).

T-77. A New Germacrane Sesquiterpenolide Isolated from Artemisia frigida
Man-Li Zhang, Zhi-Yu Ni, Cun-Fang Li, Yu-Fang Wang, Mei Dong, Françoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong, Chem. Nat. Compds., 49(4), 626-628 (2013).

T-73. Cytotoxic Flavonoids from the Flowers of Achillea millefolium
Chang-Hong Huo, Yong Li, Mei Dong, Man-Li Zhang, Yu-Fang Wang, Qing Zhang, Fang Qin, Qing-Wen Shi, Hiromasa Kiyota, Chem. Nat. Cmpds., 48(6), 958-962 (2013), .

T-70. Antitumor Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica
Yong Li, Bin Cong, Si-Ming Wang, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Hiromasa Kiyota, Qing-Wen Shi, Z. Naturforsch., 67c(7-8), 375-380 (2012).

T-69. Millefolide A-C, 1,10-Seco-guaianolides from the Flowers of Achillea millefolium
Yong Li, Zhi-Yu Ni, Meng-Chu Zhu, Kai Zhang, Yi-Bing Wu, Mei Dong, Qing-Wen Shi, Chang-Hong Huo, Françoise Sauriol, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong, Z. Naturforsch., 67b(4), 438-446 (2012), 10.5560/ZNB.2012-0028.

T-67. Achillinin B and C, New Sesquiterpene Dimers Isolated from Achilliea milleforium
Yong Li, Bin Cong, Si-Ming Wang, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Hiromasa Kiyota, Qing-Wen Shi, Tetrahedron Lett., 53(21), 2601-2603 (2012), 10.1016/j.tetlet.2012.03.039.

T-62. Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow, Achillea millefolium
　　Y. Li, M.-L. Zhang, B. Cong, S.-M. Wang, M. Dong, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-C. Gu, H. Kiyota, Biosci. Biotechnol. Biochem., 75, 1554-1556.

T-99. Chemical Constituents of Plants from the Genus CarpesiumREVIEW
Hui-Min Yan, Hao-Ran Wen, Yu-Fang Wang, Shao-Jing Li, Zhao-Xin Zhang, Yi-Bing Wu, Man-Li Zhang, Yu-Cheng Gu, Mao-Chang Ji, Hiromasa Kiyota, Curr. Top. Phytochemistry, 18, 1-10 (2023).

T-95. Chemical Constituents and Their Activities from Saussurea GenusREVIEW
Ting Zhao, Shao-Jing Li, Zhao-Xin Zhang, Man-Li Zhang, Qing-Wen Shi, Yu-Cheng Gu, Mei Dong, Hiromasa Kiyota, Heterocycl. Commun., 23(5), 331-358 (2017), 10.1515/hc-2017-0069.

T-93. Chemical and Pharmacological Research of the Plants from Genus AjugaREVIEW
Xia Qing, Hui-Min Yan, Zhi-Yu Ni, Christopher J. Vavricka, Man-Li Zhang, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Heterocycl. Commun., 23(4), 245-268 (2017), 10.1515/hc-2017-0064.

T-89. Recearch Advances on Biological Activities of Tanshinone IIA- a Mini ReviewREVIEW
Yan Zhong, Man-Li Zhang, Jin-Sheng Qi, Qing-Wen Shi, Hiromasa Kiyota, Mini Rev. Org. Chem., 13(4), 305-311 (2016), 10.2174/1570193X13666160614084004.

T-82. Chemical Constituents of Plants from the Genus NeolitseaREVIEW
Xia Qing, Ting Zhao, Rui-Xia Guo, Yi-Bing Wu, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Heterocycl. Commun., 20(2), 61-75 (2014), 10.1515/hc-2013-0239.

T-72. Constituents from Salvia species and their Biological Activities
Yi-Bing Wu, Zhi-Yu Ni, Qing-Wen Shi, Mei Dong, Hiromasa Kiyota, Yu-Cheng Gu, Bin Cong, Chem. Rev., 112(11), 5967-6026 (2012), 10.1021/cr200058f.

T-61. Chemical and Pharmacological Research of the Plants of Genus Caesalpinia [REVIEW]
Yan Yang, Lei Zhao, Chang-Hong Huo, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 8, 1370-1399 (2011).

T-56. Chemical and Pharmacological Research of the Plants of Genus Senecio [REVIEW]
Yan Yang, Lei Zhao, Yu-Fang Wang, Man-Li Chang, Chang-Hong Huo, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 8, 13-72 (2011).

T-55. Secondary Metabolites of Plants from Genus Saussurea: Chemistry and Biological Activity [REVIEW]
Yu-Fang Wang, Zhi-Yu Ni, Mei Dong, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Chem. Biodivers., 7, 2623-2659 (2010).

T-53. Chemical Constituents of Plants from the Genus Valeriana [REVIEW]
Y.-F. Wang, L.-Q. Jin, S.-H. Yu, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Mini-Rev. Org. Chem., 7(2), 161-172 (2010).

T-51. The Daphniphyllum Alkaloids [REVIEW]
M. Dong, M.-L. Zhang, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Curr. Org. Chem., 13(6), 646-682.

T-46. Chemical and Pharmacological Studies of the Plants from Genus Celastrus [REVIEW]
X.-H. Su, M.-L. Zhang, W.-H. Zhan, C.-H. Huo, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Chem. Biodivers., 6 (2), 146-161 (2009).

T-44. Chemical Constituents of the Plants in Genus Euphorbia [REVIEW]
X.-H. Su, Q.-W. Shi, H. Kiyota, Chem. Rev., 108(10), 4295-4327 (2008).

T-42. Chemical and Pharmacological Research of the Plants from Genus Celastrus [REVIEW]
X.-H. Su, M. Dong, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Natural Products: Chemistry, Biochemistry and Pharmacology, c10, 270-292 (2008).

T-32. Chemical Constituents in the Genus Wedelia and their Bioactivity [REVIEW]
X. Li, Y. Liu, Q.-W. Shi, H. Kiyota, Chem. Biodivers., 4, 823-836 (2007).

T-29. Chemical Constituents of the Plants in Genus Laggera [REVIEW]
X.-C. Li, C.-H. Huo, Q.-W. Shi, H. Kiyota, Chem. Biodivers., 4, 105-111 (2007).

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「ハクモクレン成熟果に含まれる新規なフェノール誘導体」2009.7 （研究主催：野下俊朗 先生）

ハクモクレン(Magnolia denudata) の花蕾を乾燥させたものは生薬「辛夷」として用いられることから、これまでに花蕾や葉、樹皮の成分研究がなされています。成熟果の成分として既知化合物のdenudatine A に加え、二種の新規なフェノール誘導体を得ました。
共同研究先：野下俊朗先生（広島県立大学）、村山哲也先生（山形大学）、猟山一雄先生（青森大学）
133. "New Cytotxic Phenolic Derivatives from Matured Fruits of Magnolia denudata"
　　T. Noshita, H. Kiyota, Y. Kidachi, K. Ryoyama, S. Funayama, K. Hanada, T. Murayama, Biosci. Biotechnol. Biochem., 73, 726-728 (2009).

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