Structure-Activity Relationships of Taxoids
Semi-synthetic studies of novel taxoids from naturally abundant taxinine were investigated.
12. Synthesis and biological evaluation of 1-deoxy-4,7-dideacetoxy azetidine paclitaxel analogs
11. Synthesis and biological activity of (2-m-substituted)benzoyl)baccatin III analogs from taxinine
T. Horiguchi, T. Oritani, H. Kiyota, Tetrahedron, 59, 1529-1538 (2003).
¡¡¡¡Q. Cheng, H. Kiyota, M. Yamaguchi, T. Horiguchi, T. Oritani, Bioorganic and Medicinal Chemistry Letters, 13, 1075-1077 (2003).
Isolation and Structure Determination of Novel TAXOIDS
T-X. Natural Taxanes: Developments Since 1828 [REVIEW]
Mei Dong, Yu-Fang Wang, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Chemical Reviews, in press.T-X. Novel Taxa-4(20),12-diene and 2(3->20)Abeotaxane from the Needles of Taxus canadensis
Zhi-Yu Ni, Yi-Bing Wu, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Francoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Bin Cong, Biosci. Biotechnol. Biochem., in press.T-61. Chemical and Pharmacological Research of the Plants of Genus Caesalpinia [REVIEW]
Yan Yang, Lei Zhao, Chang-Hong Huo, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 8, 1370-1399.T-60. A Novel Taxtetraene Framework formed from a New Natural Taxane from Taxus cuspidata
Yong Li, Yong-Li Wang, Zhi-Yu Ni, Mei Dong, Bin Cong, Francoise Sauriol, Man-Li Zhang, Yu-Fang Wang, Chang-Hong Huo, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Z. Naturforsch., 66b, 759-761.T-59. The First Taxane peroxide from the Rooted Cuttings of Taxus canadensis
Man-Li Zhang, Yu-Fang Wang, Mei Dong, Chang-Hong Huo, Francoise Sauriol, Qing-Wen Shi, Hiromasa Kiyota, Hetercycl. Commun., 17, 87-91.T-58. A Novel Taxane 13-Glucoside and Other Taxanes from the Leaves of Taxus cuspidata
Zhi-Yu Ni, Mei Dong, Bin Cong, Francoise Sauriol, Man-Li Zhang, Yu-Fang Wang, Chang-Hong Huo, Qing-Wen Shi, Hiromasa Kiyota, Planta Med., 77, 281-283.T-57. Oxepinamides: Novel Liver X Receptor Agonists form Aspergillus puniceus
Xin-Hua Lu,Qing-Wen Shi, Zhi-Hui Zheng, Ai-Bing Ke, Hua Zhang, Chang-Hong Huo, Ying Ma, Xiao Ren, Ye-Ying Li, Jie Lin, Qin Jiang, Yu-Cheng Gu, Hiromasa Kiyota, Eur. J. Org. Chem., 802-807.T-56. Chemical and Pharmacological Research of the Plants of Genus Senecio [REVIEW]
Yan Yang, Lei Zhao, Yu-Fang Wang, Man-Li Chang, Chang-Hong Huo, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 8, 13-72.T-55. Secondary Metabolites of Plants from Genus Saussurea: Chemistry and Biological Activity [REVIEW]
Yu-Fang Wang, Zhi-Yu Ni, Mei Dong, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Chem. Biodivers., 7, 2623-2659.T-54. Two New Phytoecdysteroids from the Needles of Taxus canadensis
Yu Fang, Zhi-Yu Ni, Teiko Yamada, Yu-Fang Wang, Man-Li Zhang, Mei Dong, Bin Cong, Francoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Hiromasa Kiyota, Z. Naturforsch., 65b, 1401-1405.T-53. Chemical Constituents of Plants from the Genus Valeriana [REVIEW]
Y.-F. Wang, L.-Q. Jin, S.-H. Yu, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Mini-Rev. Org. Chem., 7(2), 161-172 (2010).
T-52. Xylocarponoids A and B, Unique C28 Skeleton Limonoids from Xylocarpus granatum
C.-H. Huo, D. Guo, L.-R. Shen, B.-W. Yin, F. Sauriol, L.-G. Li, M.-L. Zhang, Q.-W. Shi, H. Kiyota, Tetrahedron Lett., 51(4), 754-757 (2010).
T-51. The Daphniphyllum Alkaloids [REVIEW]
M. Dong, M.-L. Zhang, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Curr. Org. Chem., 13(6), 646-682.
T-50. Taxusecone, a Novel Taxane with an Unprecedented 11,12-Secotaxane Skeleton from Taxus cuspidata
S.-H. Yu, Z.-Y. Ni, J. Zhang, M. Dong, F. Sauriol, C.-H. Huo, Q.-W., Shi, Y.-G., Gu, H. Kiyota, B. Cong, Biosci. Biotechnol. Biochem. 73(3), 756-758 (2009).
T-49. New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata
T. Noshita, H. Kiyota, S. Funayama, K. Hanada, T. Murayama, Biosci. Biotechnol. Biochem., 73(3), 726-728 (2009).
T-48. Two New 11(15->1)Abeotaxanes with a 2,20-Epoxy Ring from the Needles of Taxus canadensis
M.-L. Zhang, J. Zhang, M. Dong, S.-H. Feng, C.-H. Huo, F. Sauriol, Q.-W. Shi, Y.-G. Gu, H. Kiyota, B. Cong, Z. Naturforsch., 64c (1), 43-49 (2009).
T-47. Xylomexicanins A and B, New ¦¤14,15-Mexicanolides from the Seeds of the Chinese Mangrove Xylocarpus granatum
L.-R. Shen, M. Dong, D. Guo, B.-W. Yin, M.-L. Zhang, Q.-W. Shi, C.-H. Huo, H. Kiyota, N. Suzuki, B. Cong, Z. Naturforsch., 64c (1), 37-42 (2009).
T-46. Chemical and Pharmacological Studies of the Plants from Genus Celastrus [REVIEW]
X.-H. Su, M.-L. Zhang, W.-H. Zhan, C.-H. Huo, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Chem. Biodivers., 6 (2), 146-161 (2009).
T-45. Taxpropellane, a Novel Taxane with an Unprecedented Polycyclic Skeleton from the Needles of Taxus canadensis
M.-L. Zhang, M. Dong, C.-H. Huo, L.-G. Li, F. Sauriol, Q.-W. Shi, Y.-G., Gu, H. Makabe, H. Kiyota, Eur. J. Org. Chem., (32), 5414-5417 (2008).
T-44. Chemical Constituents of the Plants in Genus Euphorbia [REVIEW]
X.-H. Su, Q.-W. Shi, H. Kiyota, Chem. Rev., 108(10), 4295-4327 (2008).
T-43. A New pseudo-Alkaloid Taxane and a New Rearranged Taxane from the Needles of Taxus canadensis
M.-L. Zhang, C.-H. Huo, M. Dong, L.-G. Li, F. Sauriol, Q.-W. Shi, Y.-G. Gu, H. Kiyota, and B. Cong, Z. Naturforsch., 63b (8), 1005-1011 (2008).
T-42. Chemical and Pharmacological Research of the Plants from Genus Celastrus [REVIEW]
X.-H. Su, M. Dong, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Natural Products: Chemistry, Biochemistry and Pharmacology, c10, 270-292 (2008).
T-41. Chemical Constituents in Taxus canadensis [REVIEW]
M. Dong, M.-L. Zhang, Q.-W. Shi, Y.-G. Gu, H. Kiyota, Natural Products: Chemistry, Biochemistry and Pharmacology, c9, 247-269 (2008).T-40. A New Taxane Composed of Two N-formyl Rotamers from Taxus canadensis
M.-L. Zhang, M. Dong, X.-N. Li, L.-G. Li, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-G., Gu, H. Kiyota, B. Cong, Tetrahedron Lett., 49 (21), 3405-3408 (2008).
T-39. Echinopines A and B: Sesquiterpenoids Possessing an Unprecedented Skeleton from Echinps spinosus
M. Dong, B. Cong, S.-H. Yu, F. Sauriol, C.-H. Huo, Q.-W. Shi,Y.-G. Gu, L. O. Zamir, H. Kiyota, Org. Lett., 10(5), 701-704 (2008).T-38. A Novel Taxane with a Rare 9¦Á,13¦Á-Oxygen Bridge from Taxus cuspidata Needles
M.-L. Zhang, B. Cong, M. Dong, Y.-F. Wang, C.-H. Huo, Y.-G. Gu, Q.-W. Shi, H. Kiyota, Tetrahedron Lett., 49(7), 1180-1183 (2008).
T-37. Two New Taxanes from Taxus canadensis
C.-H. Huo, Y.-M. Zhao, X.-T. Si, L.-G. Li, M.-L. Zahng, Q.-W. Shi, H. Kiyota, Biochem. Syst. Ecol., 35(12), 909-913 (2007)36. 7,8¦Â-Dihydroponasterone A, a New Phytoecdysteroid from the Needles of the Japanese Yew, Taxus cuspidata
Q.-W. Shi, M. Dong, C.-H. Huo, X.-H.i Su, X. Li, T. Yamada, H. Kiyota, J. Braz. Chem. Soc., in press (2007).35. A New Taxol Analogue from the Leaves of Taxus cuspidata
C.-H. Huo, X.-P. Zhang, C.-F. Li, Y.-F. Wang, Q.-W. Shi, H. Kiyota, Biochem. Syst. Ecol., 35(10), 704-708 (2007).34. Three New Taxanes with 10-Alkoxy Group from the Heartwood of Taxus cuspidata
M. Dong, M.-L. Zhang, Y.-F. Wang, X.-P. Zhang, C.-F. Li, Q.-W. Shi, B. Cong, H. Kiyota, Biosci. Biotechnol. Biochem, 71(8), 2097-2080 (2007).33. New 14-Hydroxy-taxane and 2¦Á,20-Epoxy-11(15->1)abeotaxane from the Needles of Taxus canadensis
Q.-W. Shi, M. Dong, C.-H. Huo, X.-H. Su, C.-F. Li, X.-P. Zhang, Y.-F. Wang, H. Kiyota, Biosci. Biotechnol. Biochem., 71(6), 1777-1780 (2007).32. Chemical Constituents in the Genus Wedelia and their Bioactivity [REVIEW]
X. Li, Y. Liu, Q.-W. Shi, H. Kiyota, Chem. Biodivers., 4, 823-836 (2007).31. Structural Determination of a New 2(3->20)Abeotaxane with an Unusual13¦Â-Substitution and a New 6/8/6-Ring Taxane from Taxus cuspidata
C.-H. Huo, X.-H. Su, X. Li, X.-P. Zhang, C.-F. Li, Y.-F. Wang, Q.-W. Shi, H. Kiyota, Magn. Reson. Chem., 45 (6), 527-530 (2007).30. Canataxpropellane, a Novel Taxane with a Unique Polycyclic Carbon Skeleton (Tricyclotaxane) from the Needles of Taxus canadensis
C.-H. Huo, X.-H. Su, Y.-F. Wang, X.-P. Zhang, Q.-W. Shi, H. Kiyota, Tetrahedron Lett., 48, 2721-2724 (2007).29. Chemical Constituents of the Plants in Genus Laggera [REVIEW]
X.-C. Li, C.-H. Huo, Q.-W. Shi, H. Kiyota, Chem. Biodivers., 4, 105-111 (2007).28. Phytochemical Studies of Taxane Diterpenoids from Yew Trees [REVIEW]
, Chapt. 3,43-59 (2007).
Qing-Wen Shi, Hiromasa Kiyota, Recent Res. Development. Chemistry of Natural Products: Recent Trends and Developments 2006
27. A New Metabolite with a New Substituted Pattern from the Seeds of the Chinese Yew, Taxus mairei
C.-H. Huo, Y.-F. Wang, X.-P. Zhang, C.-F. Li, Q.-W. Shi, H. Kiyota, Chem. Biodivers., 4, 84-88 (2007).26. Chemical Constituents of the Plants in Genus Achillea [REVIEW]
Yong-Ming Zhao, Man-Li Zhang, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 3, 1163-1180 (2006).
25. Two New Taxanes from the Branches Bark and Needles of Taxus cuspidata
Cong-Mei Cao, Man-Li Zhang, Yu-Fang Wang, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota, Chem. Biodivers., 3, 1153-1161 (2006).
24. New Taxanes from the Seeds of Taxus mairei
Qing-Wen Shi, Zuo-Ping Li, Chun- Lin Wang, Man-Li Zhang, Nadeo Choony, H. Kiyota, J. Asian Nat. Prod. Res., 8, 431-437 (2006).23. Chemical Constituents of the Plants in Genus Inula
Yong-Ming Zhao, Man-Li Zhang, Qing-Wen Shi, Hiromasa Kiyota, Chem. Biodivers., 3, 371-384 (2006).22. Two New Alkaloidal Taxanes from the Needles of Taxus canadensis
Qing-Wen Shi, Xiao-Tang Si, Yong-Ming Zhao, Xiao-Hui Su, Xing Li, Lolita O. Zamir, T. Yamada, H. Kiyota, Bios., Biotechnol. Biochem., 70, 732-736 (2006).21. 1-Deoxypaclitaxel and abeo-Taxoids from the Seeds of Taxus mairei
Qing-Wen Shi, Yong-Ming Zhao, Xiao-Tang Si, Zuo-Ping Li, Teiko Yamada, H. Kiyota, J. Nat. Prod., 69, 280-283 (2006).20. Four New Epoxy Taxanes from the Needles of Taxus cuspidata
Qing-Wen Shi, Cong-Mei Cao, Ji-Shun Gu, Hiromasa Kiyota, Nat. Prod. Res., 20, 173-179 (2006).19. Isolation and Structure Revision of 10-Deacetyltaxinine from the Seeds of the Chinese yew, Taxus mairei
Qing-Wen Shi, Zuo-Ping Li, Ding Zhao Ji-Shun Gu, H. Kiyota, Nat. Prod. Res., 20, 47-51 (2006).18. A New Abeotaxane Diterpenoid from the Seeds of Taxus mairei
Man-Li Zhang, Li-Geng Li, Cong-Mei Cao, Zuo-Ping Li, Qing-Wen Shi, Hiromasa Kiyota, Chin. Chem. Lett., 17, 27-30 (2006).17. New Natural Taxane Diterpenoids from Taxus Species Since 1999 [REVIEW]
Qing-Wen Shi, H. Kiyota, Chemistry and Biodiversity, 2, 1597-1623 (2005).16. A Novel 3,8-Secotaxane Metabolite from the Seeds of the Chinese Yew, Taxus mairei
Qing-Wen Shi, Li-Geng Li, Zuo-Ping Li, Cong-Mei Cao, H. Kiyota, Tetrahedron Lett., 46, 6301-6303 (2005).15. First Example of 11,12-Epoxytaxane-glycoside from the Needles of Taxus cuspidata
C. Wang, M. Zhang, C. Cao, Q.-W. Shi, H. Kiyota, Heterocyclic Communications, 11, 211-214.14. Structure Elucidation and Complete NMR Spectral Assignments of a New Taxane-glycoside from the Needles of Taxus cuspidata
L. Li, C. Cao, C. Huo, M. Zhang, Q.-W. Shi, H. Kiyota, Magnetic Resonance in Chemistry, 43 (6), 475-478 (2005).13. New 2(3->20)Abeotaxane and 3,11-Cyclotaxane from Needles of Taxus cuspidata
Q.-W. Shi, Z.-P. Li, D. Zhao J.-S. Gu, T. Oritani, H. Kiyota Bioscience, Biotechnology, and Biochemistry, 68 (7), 1584-1587 (2004).10. New Taxoids Isolated from the Yew Trees in the Recent Years [REVIEW]
Q.-W. Shi, H. Kiyota and T. Oritani, Natural Product Research & Development, 11 (6), 62-78.9. A new drimane from the heartwood of the Japanese yew, Taxus cuspidata
H. Kiyota, Q.-W. Shi, T. Oritani, Natural Product Letters, 16, 21-24, (2002).8. New 11(15->1)Abeotaxane, 11(15->1),11(10->9)Bisabeotaxane and 3,11-Cyclotaxanes from Taxus yunnanensis
H. Kiyota, Q.-W. Shi, T. Oritani, L. Li, Bioscience, Biotechnology, and Biochemistry, 65 (1), 35-40 (2001).7. Three New Taxoids from the Leaves of the Japanese Yew, Taxus cuspidata
Q.-W. Shi, T. Oritani, H. Kiyota, R. Murakami, Natural Product Letters, 15, 55-62, (2001).6. New Taxane Diterpenoids from Taxus yunnanensis and Taxus cuspidata
Q.-W. Shi, T. Oritani, H. Kiyota, L. Li, Phytochemistry, 54, (8), 2000, 829-834.5. Three New Rearranged Taxane Diterpenoids from the Bark of Taxus chinensisvar. mairei and the needles of Taxus cuspidata
Q.-W. Shi, T. Oritani, T. Sugiyama, H. Kiyota and T. Horiguchi, Heterocycles, 51 (4), 841-850.4. Three New 3,8-Secotaxanes from Taxus mairei
Q.-W. Shi, T. Oritani, T. Sugiyama and H. Kiyota, Journal of Natural Products, 61(11), 1437-1440 (1998).
3. 14beta-Hydroxytaxusin, a New Taxane from Taxus mairei
Q.-W. Shi, T. Oritani and H. Kiyota, Natural Product Letters, 12(1), 85-90 (1998).
2. Two New Taxane Diterpenoids from Taxus mairei
Q.-W. Shi, T. Oritani, T. Sugiyama and H. Kiyota, Planta Medica, 64(1), 766-769 (1998).
1. Isolation and Structure Elucidation of a New 11(15->1)-Abeotaxane from the Chinese Yew, Taxus mairei
Q.-W. Shi, T. Oritani, H. Kiyota and T. Horiguchi, Natural Product Letters, 12(1), 67-74 (1998).