論文発表
"Kinetic Resolution of α-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester–Amide Exchange Reaction"
Ryota Nakao, Yudai Fujii, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura*
Synlett, eFirst
DOI: 10.1055/s-0040-1707303 LinkIcon
 

 
C1-Symmetric chiral ammonium salt catalysts induced a kinetic resolution of racemic α-nitrolactones through an asymmetric ester–amide exchange reaction.  The corresponding amides were obtained with high enantioselectivities and high S (= kfast/kslow) values.  This reaction system is a useful approach for obtaining carbocyclic quaternary α-nitroamides as chiral building blocks.
(2020.10.8)

論文発表
"Enantioselective Diels–Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts"
Yudai Fujii, Ryota Nakao, Saki Sugihara, Keita Fujita, Yuya Araki, Takayuki Kudoh, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura*
Synlett, eFirst
DOI: 10.1055/s-0040-1707302 LinkIcon
 

 
An enantioselective Diels–Alder reaction of 3-nitrocoumarins has been developed.  A tryptophan-derived C1-symmetric organoammonium thiourea catalyst promoted the reaction of 3-nitrocoumarins with Danishefsky’s diene to give the corresponding adducts with good enantioselectivity (up to 94% ee).  One of the resulting adducts was converted into a chiral carbocyclic quaternary β-amino alcohol.
(2020.10.7)

学生の立ち入り制限が緩和されたため,研究活動を再開しました。
(2020.6.8)


COVID-19で学生が自宅待機となっているため,オンラインにてセミナーを実施しています。
(2020.4.20)


新メンバーを迎えて2020年度がスタートしました。
(2020.4.1)


早川一郎准教授が日本大学文理学部教授に栄転されました。
(2020.4.1)