岡山大学 工学部 化学生命系学科/大学院自然科学研究科 応用化学専攻

生物有機化学研究室
坂倉研究室/SAKAKURA Group



更新日: 2017-10-10

学会発表

ユズリハアルカロイド・ユズリミン類の合成研究
早川一郎,池田将規,新井田恵介,中重雄一,永易杏菜,野村紗希,齊藤啓太,木越英夫,坂倉彰
第59回天然有機化合物討論会,ポスター発表,わくわくホリデーホール(札幌市民ホール),9月20日〜22日,P-33
(2017.9.22)

講演会

シストセンチュウふ化促進物質の不斉全合成
谷野 圭持 教授(北海道大学大学院理学研究院)
2017年9月14日
P1020648.JPGP1020648.JPGP1020656 4.JPGP1020656 4.JPGP1020661.JPGP1020661.JPG
P1020659.JPGP1020659.JPGP1020654.JPGP1020654.JPGP1020663.JPGP1020663.JPG
(2017.9.15)

集中講義

谷野 圭持 教授(北海道大学大学院理学研究院)
2017年9月14日,15日
(2017.9.15)

論文発表

Heat Versus Basic Conditions: Intramolecular Dehydro-Diels–Alder Reaction of 1-Indolyl-1,6-heptadiynes for the Selective Synthesis of Substituted Carbazoles
Takayuki Kudoh, Syo Fujisawa, Megumi Kitamura, Akira Sakakura*
Synlett 2017, 28, 2189–2193.
DOI: 10.1055/s-0036-1588461
GA-carbazole.png
The intramolecular dehydro-Diels–Alder reaction of 1-indolyl-1,6-heptadiynes proceeds smoothly under rather mild heating conditions to give substituted carbazoles in moderate to good yields. The reaction of 7-aryl-1-indolyl-1,6-heptadiynes under heating gives the corresponding carbazoles chemoselectively in high yields, whereas the reaction under basic conditions gives naphthalenes as major products.
(2017.7.6)

招待講演

"Biomimetic Cyclization of 3,5-Diketoesters: Application to Total Synthesis of Cyercene A, an α-Methoxy-γ-Pyrone-Containing Polypropionate"
Akira Sakakura
International Symposium on Pure & Applied Chemistry (ISPAC) 2017
Hotel Continental Saigon, Ho Chi Minh City, Vietnam, June 8–10, 2017
Oral Presentation, ORG42
(2017.6.10)

学会発表

"Total Synthesis of Manzacidins A and C Based on Diastereoselective Hydroxymethylation of Chiral Nitroalkanes"
Yuya Araki, Mizuho Tanioka, Natsumi Miyoshi, Takayuki Kudoh, Akira Sakakura
International Symposium on Pure & Applied Chemistry (ISPAC) 2017
Hotel Continental Saigon, Ho Chi Minh City, Vietnam, June 8–10, 2017
Oral Presentation, ORG67
(2017.6.10)

論文発表

Reinvestigation of the Biomimetic Cyclization of 3,5-Diketoesters: Application to the Total Synthesis of Cyercene A, an α-Methoxy-γ-Pyrone-Containing Polypropionate
Kai Onda, Ichiro Hayakawa, Akira Sakakura*
Synlett 2017, 28 (13), 1596–1600.
DOI: 10.1055/s-0036-1588795
GA-gamma-pyrone.png
The biomimetic cyclization of 3,5-diketoesters was reinvestigated for the synthesis of α-methoxy-γ-pyrones. 3,5-Diketoesters were selectively synthesized via the aldol reaction of commercially available methyl 2-methyl-3-oxopentanoate with an aldehyde followed by the oxidation with AZADOL® and PhI(OAc)2. The DBU-promoted intramolecular transesterification of 3,5-diketoesters showed excellent reactivity in MeOH, to give the corresponding γ-hydroxy-α-pyrones in high yields under mild reaction conditions. Based on the present cyclization scheme, the total synthesis of cyercene A was achieved.
(2017.4.26)

2017年度始動

M2 6人,M1 3人,B4 10人とともに,2017年度がスタートしました。
(2017.4.3)

当研究室では,複雑な骨格や多彩な官能基を持つ生物活性物質の全合成や,有機触媒を利用した不斉合成法の開発に取り組んでいます。