Haruki MIZOGUCHI
Division of Applied Chemistry
Graduate School of Natural Science and Technology
Okayama University
Associate Professor
3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
TEL: 086-251-8211
E-mail: h_mizoguchi
ORCID: 0000-0002-2148-9699
Education & Career
Hokkaido University, Graduated 2008 (Prof. H. Oikawa, Assoc. Prof. H. Oguri)
2010 M.Sc. Hokkaido University
(Prof. H. Oikawa, Assoc. Prof. H. Oguri)
2013 Ph.D. Hokkaido University (Prof. H. Oikawa, Assoc. Prof. H. Oguri)
Dartmouth College, USA 2013–2017, Post. Dr.
(Prof. G. C. Micalizio)
Okayama University 2017–, Assistant Professor
(Prof. A. Sakakura)
Award
Hokkaido University Clark award (2008)
21st Banyu Sapporo Symposium poster award (2010)
Otsu Academy Award Fellow (2010)
102nd Symposium on The Society of Organic Chemistry, poster award (2012)
Reaxys PhD Prize 2014 Finalist (2014)
Young Scientist's Research Award in Natural Product Chemistry (2018)
Publication List
1. “Divergent and Expeditious Access to Fused Skeletons Inspired by Indole Alkaloids and Transtaganolides”
Haruki Mizoguchi, Hiroki Oguri, Kiyoshi Tsuge, Hideaki Oikawa, Org. Lett. 2009, 11 (14), 3016–3019.
DOI: 10.1021/ol901020a
2. “Hg(OTf)2-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions”
Haruki Mizoguchi, Hideaki Oikawa, Hiroki Oguri, Org. Biomol. Chem. 2012, 10 (21), 4236–4242.
DOI: 10.1039/C2OB25236H
3. “Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization”
Hiroki Oguri, Haruki Mizoguchi, Hideaki Oikawa, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Beilsterin J. Org. Chem. 2012, 8, 930–940.
DOI: 10.3762/bjoc.8.105
4. “Biogenetically inspired synthesis and skeletal diversification of indole alkaloids”
Haruki Mizoguchi, Hideaki Oikawa, Hiroki Oguri, Nat. Chem. 2014, 6 (1), 57–64.
DOI: 10.1038/nchem.1798
5. “Synthesis of Angularly Substituted Trans-Fused Hydroindanes by Convergent Coupling of Acyclic Precursors”
Valer Jeso, Claudio Aquino, Xiayun Cheng, Haruki Mizoguchi, Mika Nakashige, Glenn C. Micalizio, J. Am. Chem. Soc. 2014, 136 (23), 8209–8212.
DOI: 10.1021/ja504374j
6. “LiOOt-Bu as a terminal oxidant in a titanium alkoxide-mediated [2+2+2] reaction cascade”
Wan Shin Kim, Claudio Aquino, Haruki Mizoguchi, Glenn C. Micalizio, Tetrahedron Lett. 2015, 56 (23), 3557–3559.
DOI: 10.1016/j.tetlet.2015.01.029
7. “Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization”
Haruki Mizoguchi, Ryo Watanabe, Shintaro Minami, Hideaki Oikawa, Hiroki Oguri, Org. Biomol. Chem. 2015, 13 (21), 5955–5963.
DOI: 10.1039/C5OB00356C
8. “Synthesis of Highly Functionalized Decalins via Metallacycle-Mediated Cross-Coupling”
Haruki Mizoguchi, Glenn C. Micalizio, J. Am. Chem. Soc. 2015, 137 (20), 6624–6628.
DOI: 10.1021/jacs.5b02107
9. “Acceleration of metallacycle-mediated alkyne-alkyne cross-coupling with TMSCl”
James S. Cassidy, Haruki Mizoguchi, Glenn C. Micalizio, Tetrahedron Lett. 2016, 57 (34), 3848–3850.
DOI: 10.1016/j.tetlet.2016.07.045
10. “Synthesis of Angularly Substituted trans-Fused Decalins through a Metallacycle-Mediated Annulative Cross-Coupling Cascade”
Haruki Mizoguchi, Glenn. C. Micalizio, Angew. Chem. Int. Ed. 2016, 55 (42), 13099–13103.
DOI: 10.1002/anie.201606962
11. “Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents”
Ryo Watanabe, Haruki Mizoguchi, Hideaki Oikawa, Hirofumi Ohashi, Koichi Watashi, Hiroki Oguri, Bioorg. Med. Chem. 2017, 25 (11), 2851–2855.
DOI: 10.1016/j.bmc.2017.03.011
12. "Design and De Novo Synthesis of 6-Aza-artemisinins"
Karunakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikara, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Hiroki Oguri, Org Lett. 2018, 20 (15), 4667-4671.
DOI: 10.1021/acs.orglett.8b01987
13. "Thioureas as Highly Active Catalysts for Biomimetic Bromocyclization of Geranyl Derivatives"
Miyuki Terazaki, Kei-ichi Shiomoto, Haruki Mizoguchi, Akira Sakakura,* Org. Lett. 2019, 21 (7), 2073–2076.
DOI: 10.1021/acs.orglett.9b00352
14. "Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with α-(Acyloxy)acroleins Catalyzed by Dipeptide-Derived Chiral Tri- or Diammonium Salts"
Chihiro Kidou, Haruki Mizoguchi, Tatsuo Nehira, Akira Sakakura,* Synlett 2019, 30 (15), 1835–1839.
DOI: 10.1055/s-0039-1690133
15. "Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds"
Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda,* Hiroki Oguri,* Chem. Sci. 2019, 10 (22), 5686–5698.
DOI: 10.1039/C9SC01507H
16. "Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction"
Yuya Araki, Natsumi Miyoshi, Kazuki Morimoto, Takayuki Kudoh, Haruki Mizoguchi, Akira Sakakura,* J. Org. Chem. 2020, 85 (2), 798–805.
DOI: 10.1021/acs.joc.9b02811
17. "Enantioselective Diels–Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts"
Yudai Fujii, Ryota Nakao, Saki Sugihara, Keita Fujita, Yuya Araki, Takayuki Kudoh, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura,* Synlett, eFirst.
DOI: 10.1055/s-0040-1707302
18. "Kinetic Resolution of α-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester–Amide Exchange Reaction"
Ryota Nakao, Yudai Fujii, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura,* Synlett, eFirst.
DOI: 10.1055/s-0040-1707303
79. "Synthesis of functionalized cyclopropylboronic esters based on a 1,2-metallate rearrangement of cyclopropenylboronate"
Haruki Mizoguchi,* Masaya Seriua, Akira Sakakura,* Chem. Commun., Advance Article.
DOI: 10.1039/d0cc07134j