Akira SAKAKURA
Division of Applied Chemistry
Graduate School of Natural Science and Technology
Okayama University
Professor
3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
TEL&FAX: 086-251-8215
E-mail: sakakura
ORCID: 0000-0002-2995-1251
ResearcherID: A-6319-2013
Education & Career
Nagoya University, Graduated 1993
(Prof. K. Yamada)
1995 M.Sc. Nagoya University
(Prof. K. Yamada)
2000 Ph.D. Nagoya University (Prof. Y. Hayakawa)
Nagoya University 2000–2001, Post. Dr.
(Prof. S. Murata)
University of Tsukuba 2001–2003, Assistant Professor
(Prof. H. Kigoshi)
Nagoya University 2003–2012, Associate Professor
(Prof. K. Ishihara)
Okayama University 2012–, Professor
Award
Banyu Pharmaceutical Award in Synthetic Organic Chemistry, Japan (2005)
Lectureship Award of Young Generation Special Forum from the Chemical Society of Japan (2006)
Thieme Chemistry Journal Award (2006)
Incentive Award in Synthetic Organic Chemistry, Japan (2008)
Banyu Chemist Award (2009)
Asian Core Program Lectureship Award (2010)
Publication List
1. "Synthetic Studies on Aplyronine A, a Potent Antitumor Substance of Marine Origin: Stereocontrolled Synthesis of the C21–C34 Segment"
Hideo Kigoshi, Makoto Ojika, Kiyotake Suenaga, Tsuyoshi Mutou, Junko Hirano, Akira Sakakura, Takeshi Ogawa, Masanori Nisiwaki, Kiyoyuki Yamada,* Tetrahedron Lett. 1994, 35, 1247–1250.
DOI: 10.1016/0040-4039(94)88035-2
2. "Total Synthesis of Aplyronine A, a Potent Antitumor Substance of Marine Origin"
Hideo Kigoshi, Makoto Ojika, Takeshi Ishigaki, Kiyotake Suenaga, Tsuyoshi Mutou, Akira Sakakura, Takeshi Ogawa, Kiyoyuki Yamada,* J. Am. Chem. Soc. 1994, 116, 7443–7444.
DOI: 10.1021/ja00095a072
3. "Absolute Stereochemistry and Synthesis of Aplyronines B and C, the Congeners of Aplyronine A, a Potent Antitumor Substance of Marine Origin"
Kiyotake Suenaga, Takeshi Ishigaki, Akira Sakakura, Hideo Kigoshi, Kiyoyuki Yamada,* Tetrahedron Lett. 1995, 36, 5053–5056.
DOI: 10.1016/0040-4039(95)00921-X
4. "Aplyronine A, a Potent Antitumor Substance of Marine Origin, Aplyronines B and C, and Artificial Analogues: Total Synthesis and Structure–Cytotoxicity Relationships"
Hideo Kigoshi, Kiyotake Suenaga, Tsuyoshi Mutou, Takeshi Ishigaki, Toshiyuki Atsumi, Hiroyuki Ishiwata, Akira Sakakura, Takeshi Ogawa, Makoto Ojika, Kiyoyuki Yamada,* J. Org. Chem. 1996, 61, 5326–5351.
DOI: 10.1021/jo9606113
5. "A Novel Approach to Oligodeoxyribonucleotides Bearing Phosphoric Acid Esters at the 3’-Terminals via the Phosphoramidite Method with Allyl Protection: an Efficient Synthesis of Base-Labile Nucleotide–Amino Acid and –Peptide Conjugates"
Akira Sakakura, Yoshihiro Hayakawa,* Hitoshi Harada, Masaaki Hirose, Ryoji Noyori,* Tetrahedron Lett. 1999, 40, 4359–4362.
DOI: 10.1016/S0040-4039(99)00748-0
6. "A Novel Synthesis of Oligonucleotide–Peptide Conjugates with a Base-Labile Phosphate Linker between the Two Components According to the Allyl-Protected Phosphoramidite Strategy"
Akira Sakakura, Yoshihiro Hayakawa,* Tetrahedron 2000, 56, 4427–4435.
DOI: 10.1016/S0040-4020(00)00376-8
7. "A Facile Synthesis of 5’-End Solid-Anchored, 3’-End Free Oligodeoxyribonucleotides via the (5’→3’)-Elongated Phosphoramidite Strategy"
Akira Sakakura, Yoshihiro Hayakawa,* Nucleosides, Nucleotides, Nucleic Acids 2001, 20, 213–227.
DOI: 10.1081/NCN-100002082
8. "Acid/Azole Complexes as Highly Effective Promoters in the Synthesis of DNA and RNA Oligomers via the Phosphoramidite Method"
Yoshihiro Hayakawa,* Rie Kawai, Akiyoshi Hirata, Jun-ichiro Sugimoto, Masanori Kataoka, Akira Sakakura, Masaaki Hirose, and Ryoji Noyori, J. Am. Chem. Soc. 2001, 123, 8165–8176.
DOI: 10.1021/ja010078v
9. "Effect of Molecular Sieves in the Liquid-Phase Synthesis of Nucleotides via the Phosphoramidite Method"
Yoshihiro Hayakawa,* Akiyoshi Hirata, Jun-ichiro Sugimoto, Rie Kawai, Akira Sakakura, Masanori Kataoka, Tetrahedron 2001, 57, 8823–8826.
DOI: 10.1016/S0040-4020(01)00880-8
10. "Jolkinolide D Pharmacophore: Synthesis and Reaction with Amino Acids, Nucleosides, and DNA"
Akira Sakakura, Yui Takayanagi, Hideo Kigoshi,* Tetrahedron Lett. 2002, 43, 6055–6058.
DOI: 10.1016/S0040-4039(02)01195-4
11. "Nonspecificity Induces Chiral Specificity in the Folding Transition of Giant DNA"
Michiko Ito, Akira Sakakura, Naomi Miyazawa, Shizuaki Murata,* Kenichi Yoshikawa, J. Am. Chem. Soc. 2003, 125, 12714–12715.
DOI: 10.1021/ja036745x
12. "Jolkinolide D Pharmacophore: Synthesis and Reaction with Biomolecules"
Akira Sakakura, Yui Takayanagi, Hiroki Shimogawa, Hideo Kigoshi,* Tetrahedron 2004, 60, 7067–7075.
DOI: 10.1016/j.tet.2003.08.080
13. "Synthesis and actin-depolymerizing activity of mycalolide analogs"
Kiyotake Suenaga, Saori Miya, Takeshi Kuroda, Tomohisa Handa, Kengo Kanematsu, Akira Sakakura, Hideo Kigoshi,* Tetrahedron Lett. 2004, 45, 5383–5386.
DOI: 10.1016/j.tetlet.2004.05.078
14. "Spongiacysteine, a Novel Cysteine Derivative from Marine Sponge Spingia sp."
Keiko Kobayashi, Hiroki Shimogawa, Akira Sakakura, Toshiaki Teruya, Kiyotake Suenaga, Hideo Kigoshi,* Chem. Lett. 2004, 33, 1262–1263.
DOI: 10.1246/cl.2004.1262
15. "Formal Synthesis of Optically Active Ingenol via Ring-Closing Olefin Methathesis"
Kazushi Watanabe, Yuto Suzuki, Kenta Aoki, Akira Sakakura, Kiyotake Suenaga, Hideo Kigoshi,* J. Org. Chem. 2004, 69, 7802–7808.
DOI: 10.1021/jo048833l
16. "Bulky Diarylammonium Arenesulfonates as Selective Esterification Catalysts"
Kazuaki Ishihara,* Shoko Nakagawa, Akira Sakakura, J. Am. Chem. Soc. 2005, 127, 4168–4169.
DOI: 10.1021/ja050223v
17. "Molybdenum Oxides as Highly Effective Dehydrative Cyclization Catalysts for the Synthesis of Oxazolines and Thiazolines"
Akira Sakakura, Rei Kondo, Kazuaki Ishihara,* Org. Lett. 2005, 7, 1971–1974.
DOI: 10.1021/ol050543j
18. "Selective Synthesis of Phosphate Monoesters by Dehydrative Condensation of Phosphoric Acid and Alcohols Promoted by Nucleophilic Bases"
Akira Sakakura, Mikimoto Katsukawa, Kazuaki Ishihara,* Org. Lett. 2005, 7, 1999–2002.
DOI: 10.1021/ol0504796
19. "Bulky diarylammonium arenesulfonates as mild and extremely active dehydrative ester condensation catalysts"
Akira Sakakura, Shoko Nakagawa, Kazuaki Ishihara,* Tetrahedron 2006, 62, 422–433.
DOI: 10.1016/j.tet.2005.09.059
20. "Study of the Interaction between Actin and Antitumor Substance Aplyronine A with a Novel Fluorescent Photoaffinity Probe"
Takeshi Kuroda, Kiyotake Suenaga, Akira Sakakura, Tomohisa Handa, Kazuhito Okamoto, Hideo Kigoshi,* Bioconjugate Chem. 2006, 17, 524–529.
DOI: 10.1021/bc050324i
21. "Chiral 1,1'-Binaphthyl-2,2'-diammonium Salt Catalysts for the Enantioselective Diels–Alder Reaction with α-Acyloxyacroleins"
Akira Sakakura, Kenji Suzuki, Kazuhiko Nakano, Kazuaki Ishihara,* Org. Lett. 2006, 8, 2229−2232.
DOI: 10.1021/ol060490l
22. "Enantioselective Diels–Alder Reaction of α-Acyloxyacroleins Catalyzed by Chiral 1,1'-Binaphthyl-2,2'-diammonium Salts"
Akira Sakakura, Kenji Suzuki, Kazuaki Ishihara,* Adv. Synth. Catal. 2006, 348, 2457–2465.
DOI: 10.1002/adsc.200600322
23. "Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin"
Kiyotake Suenaga, Hiroshi Hoshino, Takanori Yoshii, Kazunori Mori, Hiroki Sone, Yuhki Bessho, Akira Sakakura, Ichiro Hayakawa, Kiyoyuki Yamada, Hideo Kigoshi,* Tetrahedron 2006, 62, 7687–7698.
DOI: 10.1016/j.tet.2006.05.077
24. "Synthesis and biological activity of mycalolide analogs"
Kiyotake Suenaga,* Tomoyuki Kimura, Takeshi Kuroda, Keita Matsui, Saori Miya, Satomi Kuribayashi, Akira Sakakura, Hideo Kigoshi,* Tetrahedron 2006, 62, 8278–8290.
DOI: 10.1016/j.tet.2006.06.046
25. "The Oxorhenium(VII)-Catalyzed Direct Condensation of Phosphoric Acid with an Alcohol"
Akira Sakakura, Mikimoto Katsukawa, Kazuaki Ishihara,* Angew. Chem. Int. Ed. 2007, 46, 1423–1426.
DOI: 10.1002/anie.200604333
26. "Enantioselective halocyclization of polyprenoids induced by nucleophilic phosphoramidites"
Akira Sakakura, Atsushi Ukai, Kazuaki Ishihara,* Nature 2007, 455, 900–903.
DOI: 10.1038/nature05553
27. "Dehydrative Cyclization Catalyzed by the Combination of Molybdenum(VI) Oxides and Benzoic Acids: First Synthesis of the Antitumor Substance BE-70016"
Akira Sakakura, Shuhei Umemura, Rei Kondo, Kazuaki Ishihara,* Adv. Synth. Catal. 2007, 349, 551–555.
DOI: 10.1002/adsc.200600550
28. "Unusual Rate-Acceleration in the Brønsted Acid-Catalyzed Dehydration Reactions: Local Hydrophobic Environment in Aggregated N-(2,6-Diphenylphenyl)-N-mesitylammonium Pentafluorobenzenesulfonates"
Akira Sakakura, Hitoshi Watanabe, Shoko Nakagawa, Kazuaki Ishihara,* Chem. Asian J. 2007, 2, 477–483.
DOI: 10.1002/asia.200600380
29. "Catalytic Synthesis of Peptide-Derived Thiazolines and Oxazolines Using Bis(quinolinolato)dioxomolybdenum(VI) Complexes"
Akira Sakakura, Rei Kondo, Shuhei Umemura, Kazuaki Ishihara,* Adv. Synth. Catal. 2007, 349, 1641–1646.
DOI: 10.1002/adsc.200700068
30. "Direct ester condensation catalyzed by bulky diarylammonium pentafluorobenzenesulfonates"
Akira Sakakura, Shoko Nakagawa, Kazuaki Ishihara,* Nature Protocols 2007, 2, 1746–1751.
DOI: 10.1038/nprot.2007.254
31. "Bulky phosphazenium cation catalysis for dehydrative condensation of phosphoric acid with alcohols"
Akira Sakakura, Mikimoto Katsukawa, Takaomi Hayashi, Kazuaki Ishihara,* Green Chem. 2007, 9, 1166–1169.
DOI: 10.1039/B707974E
32. "Widely Useful DMAP-Catalyzed Esterification under Auxiliary Base- and Solvent-Free Conditions"
Akira Sakakura, Kimio Kawajiri, Takuro Ohkubo, Yuji Kosugi, Kazuaki Ishihara,* J. Am. Chem. Soc. 2007, 129, 14775–14779.
DOI: 10.1021/ja075824w
33. "Selective Synthesis of Cyclic Phosphoric Acid Diesters Through Oxorhenium(VII)-Catalyzed Dehydrative Condensation of Phosphoric Acid with Alcohols"
Akira Sakakura, Masayuki Sakuma, Mikimoto Katsukawa, Kazuaki Ishihara,* Heterocycles 2008, 76, 657–665.
DOI: 10.3987/COM-08-S(N)58
34. "Convergent Total Syntheses of Fluvibactin and Vibriobactin Using Molybdenum(VI) Oxide-Catalyzed Dehydrative Cyclization as a Key Step"
Akira Sakakura, Shuhei Umemura, Kazuaki Ishihara,* Chem. Commun. 2008, 3561–3563.
DOI: 10.1039/B805880F
35. "Rate-Accelerating Effect by the Neighboring-Group Participation of Protecting Groups in the Dehydrative Cyclization of 1,3,5-Triketones"
Akira Sakakura, Hitoshi Watanabe, Kazuaki Ishihara,* Org. Lett. 2008, 10, 2569–2572.
DOI: 10.1021/ol800860p
36. "Kinetic Resolution of Racemic Carboxylic Acids by an L-Histidine-derived Sulfonamide-induced Enantioselective Esterification Reaction"
Kazuaki Ishihara,* Yuji Kosugi, Shuhei Umemura, Akira Sakakura, Org. Lett. 2008, 10, 3191–3194.
DOI: 10.1021/ol801007m
37. "Open-air and solvent-free ester condensation catalyzed by sulfuric acids"
Akira Sakakura, Yoshiki Koshikari, Kazuaki Ishihara,* Tetrahedron Lett. 2008, 49, 5017–5020.
DOI: 10.1016/j.tetlet.2008.06.058
38. "Dehydrative cyclization of serine, threonine and cysteine residues catalyzed by molybdenum(VI) oxo compounds"
Akira Sakakura, Rei Kondo, Shuhei Umemura, Kazuaki Ishihara,* Tetrahderon 2009, 65, 2102–2109.
DOI: 10.1016/j.tet.2008.12.074
39. "3-Pyrroline-1-carbonyl (Pyroc) Group: A Removable Protecting Group for the Kinetic Resolution of Racemic Carboxylic Acids and Alcohols through Catalytic Asymmetric Acylation"
Akira Sakakura, Shuhei Umemura, Kazuaki Ishihara,* Synlett 2009, 1647–1650.
DOI: 10.1055/s-0029-1217321
40. "Rational Design of Highly Effective Asymmetric Diels-Alder Catalysts Bearing 4,4′-Sulfonamidomethyl Groups"
Akira Sakakura, Rei Kondo, Yuki Matsumura, Matsujiro Akakura, Kazuaki Ishihara,* J. Am. Chem. Soc. 2009, 131, 17762–17764.
DOI: 10.1021/ja906098b
41. "Nucleophilic Phosphine–Catalyzed Iodocyclization of Isoprenoids Bearing an Oxygen Terminal Group"
Akira Sakakura, Gakujun Shomi, Atsushi Ukai, Kazuaki Ishihara,* Heterocycles 2010, 82, 249–255.
DOI: 10.3987/COM-09-S(E)1
42. "Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Nitrones with Propioloylpyrazoles and Acryloylpyrazoles Induced by Chiral π–Cation Catalysts"
Akira Sakakura, Masahiro Hori, Makoto Fushimi, Kazuaki Ishihara,* J. Am. Chem. Soc. 2010, 132, 15550–15552.
DOI: 10.1021/ja1081603
43. "Brønsted Base-Assisted Boronic Acid Catalysis for the Dehydrative Intramolecular Condensation of Dicarboxylic Acids"
Akira Sakakura, Takuro Ohkubo, Risa Yamashita, Matsujiro Akakura, Kazuaki Ishihara,* Org. Lett. 2011, 13, 892–895.
DOI: 10.1021/ol102926n
44. "Chiral Lewis Base-Assisted Brønsted Acid (LBBA)-Catalyzed Enantioselective Cyclization of 2-Geranylphenols"
Akira Sakakura, Masayuki Sakuma, Kazuaki Ishihara,* Org. Lett. 2011, 13, 3130–3133.
DOI: 10.1021/ol201032t
45. "Desymmetrization of Meso Glycerol Derivatives Induced by L-Histidine-Derived Acylation Catalysts"
Akira Sakakura, Shuhei Umemura, Kazuaki Ishihara,* Adv. Synth. Catal. 2011, 353, 1938–1942.
DOI: 10.1002/adsc.201100252
46. "Intramolecular Dehydrative Condensation of Dicarboxylic Acids with Brønsted Base-Assisted Boronic Acid Catalysts"
Akira Sakakura, Risa Yamashita, Takuro Ohkubo, Matsujiro Akakura, Kazuaki Ishihara,* Aust. J. Chem. 2011, 64, 1458–1465.
DOI: 10.1071/CH11301
47. "Hydrophobic N,N-Diarylammonium Pyrosulfates as Dehydrative Condensation Catalysts under Aqueous Conditions"
Akira Sakakura, Yoshiki Koshikari, Matsujiro Akakura, Kazuaki Ishihara,* Org. Lett. 2012, 14, 30–33.
DOI: 10.1021/ol2027366
48. "Aplyronines D–H from the sea hare Aplysia kurodai: isolation, structures, and cytotoxicity"
Makoto Ojika,* Hideo Kigoshi, Kiyotake Suenaga, Yoshifumi Imamura, Kohji Yoshikawa, Takeshi Ishigaki, Akira Sakakura, Tsuyoshi Mutou, Kiyoyuki Yamada,* Tetrahedron 2012, 68, 982–987.
DOI: 10.1016/j.tet.2011.11.095
49. "Enantioselective Diels–Alder Reaction of α-(Acylthio)acroleins: a New Entry to Sulfur-containing Chiral Quaternary Carbons"
Akira Sakakura, Hiroki Yamada, Kazuaki Ishihara,* Org. Lett. 2012, 14, 2972–2975.
DOI: 10.1021/ol300921f
50. "N,N-Diarylammonium Pyrosulfate as a Highly Effective Reverse Micelle-type Catalyst for Hydrolysis of Esters"
Yoshiki Koshikari, Akira Sakakura, Kazuaki Ishihara,* Org. Lett. 2012, 14, 3194–3197.
DOI: 10.1021/ol301290c
51. "α-Heterosubstituted β-Alkylacroleins as Useful Multisubstituted Dienophiles for Enantioselective Diels-Alder Reactions"
Akira Sakakura, Hiroki Yamada, Kazuaki Ishihara,* Asian J. Org. Chem. 2012, 1, 133–137.
DOI: 10.1002/ajoc.201200054
52. "Kinetic Resolution of Racemic Carboxylic Acids through Asymmetric Protolactonization Promoted by Chiral Phosphonous Acid Diester"
Masayuki Sakuma, Akira Sakakura,* Kazuaki Ishihara,* Org. Lett. 2013, 15, 2838–2841.
DOI: 10.1021/ol401313d
53. "Primary Alkylboronic Acids as Highly Active Catalysts for the Dehydrative Amide Condensation of α-Hydroxycarboxylic Acids"
Risa Yamashita, Akira Sakakura,* Kazuaki Ishihara,* Org. Lett. 2013, 15, 3654–3657.
DOI: 10.1021/ol401537f
54. "Enantioselective Cyanoethoxycarbonylation of Isatins Promoted by a Lewis Base–Brønsted Acid Cooperative Catalyst"
Yoshihiro Ogura, Matsujiro Akakura, Akira Sakakura,* Kazuaki Ishihara,* Angew. Chem. Int. Ed. 2013, 52, 8299–8303.
DOI: 10.1002/anie.201303572
55. "“Phosphite–Urea” Cooperative High-Turnover Catalysts for the Highly Selective Bromocyclization of Homogeranylarenes"
Yasuhiro Sawamura, Hidefumi Nakatsuji, Akira Sakakura,* Kazuaki Ishihara,* Chem. Sci. 2013, 4, 4181–4186.
DOI: 10.1039/C3SC51432C
56. "Selective Bromocyclization of 2-Geranylphenols Promoted by Phosphite–Urea Cooperative Catalysts"
Yasuhiro Sawamura, Hidefumi Nakatsuji, Matsujiro Akakura, Akira Sakakura,* Kazuaki Ishihara,* Chirality 2014, 26, 356–360.
DOI: 10.1002/chir.22297
57. "Catalytic Enantioselective Inverse Electron Demand Hetero-Diels–Alder Reaction with Allylsilanes"
Yuki Matsumura, Takahiro Suzuki, Akira Sakakura,* Kazuaki Ishihara,* Angew. Chem. Int. Ed. 2014, 53, 6131–6134.
DOI: 10.1002/anie.201402934
58. "Cooperative Activation with Chiral Nucleophilic Catalysts and N-Haloimides: Enantioselective Iodolactonization of 4-Arylmethyl-4-pentenoic Acids"
Hidefumi Nakatsuji, Yasuhiro Sawamura, Akira Sakakura,* Kazuaki Ishihara,* Angew. Chem. Int. Ed. 2014, 53, 6974–6977.
DOI: 10.1002/anie.201400946
59. "Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Imines with Propioloylpyrazoles Induced by Chiral π−Cation Catalysts"
Masahiro Hori, Akira Sakakura,* Kazuaki Ishihara,* J. Am. Chem. Soc. 2014, 136, 13198–13201.
DOI: 10.1021/ja508441t
60. "Stereoselective Electrophilic Cyclization"
Akira Sakakura,* Kazuaki Ishihara,* Chem. Rec. 2015, 15, 728–742.
DOI: 10.1002/tcr.201500005
61. "Enantioselective Bromocyclization of 2-Gernaylphenols Induced by Chiral Phosphite-Urea Bifunctional Catalysts"
Yasuhiro Sawamura, Yoshihiro Ogura, Hidefumi Nakatsuji, Akira Sakakura,* Kazuaki Ishihara,* Chem. Common. 2016, 52, 6068–6071.
DOI: 10.1039/C6CC00229C
62. "A short access to 3,5-disubstituted piperazinones based on the aza-Michael addition of α-amino esters to β-substituted nitroalkenes"
Takayuki Kudoh,* Seiji Isoyama, Sachiko Kagimoto, Katsutoshi Kurihara, Akira Sakakura,* Tetrahedron Lett. 2016, 57, 4693–4696.
DOI: 10.1016/j.tetlet.2016.09.015
63. "Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization"
Ichiro Hayakawa,* Shuya Shioda, Takumi Chinen, Taisei Hatanaka, Haruna Ebisu, Akira Sakakura, Takeo Usui,* Hideo Kigoshi,* Bioorg. Med. Chem. 2016, 24, 5639–5645.
DOI: 10.1016/j.bmc.2016.09.026
64. "Reinvestigation of the Biomimetic Cyclization of 3,5-Diketo Esters: Application to the Total Synthesis of Cyercene A, an α-Methoxy-γ-Pyrone-Containing Polypropionate"
Kai Onda, Ichiro Hayakawa, Akira Sakakura,* Synlett 2017, 28, 1596–1600.
DOI: 10.1055/s-0036-1588795
65. "Heat Versus Basic Conditions: Intramolecular Dehydro-Diels–Alder Reaction of 1-Indolyl-1,6-heptadiynes for the Selective Synthesis of Substituted Carbazoles"
Takayuki Kudoh, Syo Fujisawa, Megumi Kitamura, Akira Sakakura,* Synlett 2017, 28, 2189–2193.
DOI: 10.1055/s-0036-1588461
66. "Diastereodivergent Henry Reaction for the Stereoselective Construction of Nitrogen-Containing Tetrasubstituted Carbons: Application to Total Synthesis of Manzacidins A and C"
Takayuki Kudoh, Yuya Araki, Natsumi Miyoshi, Mizuho Tanioka, Akira Sakakura,* Asian J. Org. Chem. 2017, 6, 1760–1763.
DOI: 10.1002/ajoc.201700568
67. "Regioselective DMAD-insertion reaction of silyl dienol ether of γ-pyrone under catalyst- and heating-free conditions"
Ichiro Hayakawa,* Yuji Yamanaka, Koichi Mitsudo, Hiromi Ota, Akira Sakakura,* Heterocycles 2017, 94, 2299–2306.
DOI: 10.3987/COM-17-13820
68. "Enantioselective Aza-Friedel–Crafts Reaction of Furan with α-Ketimino Esters Induced by a Conjugated Double Hydrogen Bond Network of Chiral Bis(phosphoric Acid) Catalysts"
Manabu Hatano, Haruka Okamoto, Taro Kawakami, Kohei Toh, Hidefumi Nakatsuji, Akira Sakakura,* Kazuaki Ishihara,* Chem. Sci. 2018, Advance Article.
DOI: 10.1039/C8SC02290A
69. "Chiral Pyrophosphoric Acid Catalysts for the para-Selective and Eanantioselective Aza-Friedel–Crafts Reaction of Phenols"
Haruka Okamoto, Kohei Toh, Takuya Mochizuki, Hidefumi Nakatsuji, Akira Sakakura,* Manabu Hatano,* Kazuaki Ishihara,* Synthesis 2018, 50 (23), 4577–4590.
DOI: 10.1055/s-0037-1610250
70. "Catalytic Enantioselective Hosomi–Sakurai Reaction of α-Ketoesters Promoted by Chiral Copper(II) Complexes"
Yutaro Niwa, Mayu Miyake, Ichiro Hayakawa, Akira Sakakura,* Chem. Commun. 2019, 55 (27), 3923–3926.
DOI: 10.1039/C9CC01159E
71. "Thioureas as Highly Active Catalysts for Biomimetic Bromocyclization of Geranyl Derivatives"
Miyuki Terazaki, Kei-ichi Shiomoto, Haruki Mizoguchi, Akira Sakakura,* Org. Lett. 2019, 21 (7), 2073–2076.
DOI: 10.1021/acs.orglett.9b00352
72. "Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with α-(Acyloxy)acroleins Catalyzed by Dipeptide-Derived Chiral Tri- or Diammonium Salts"
Chihiro Kidou, Haruki Mizoguchi, Tatsuo Nehira, Akira Sakakura,* Synlett 2019, 30 (15), 1835–1839.
DOI: 10.1055/s-0039-1690133
73. "Toward the Synthesis of Yuzurimine-type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine"
Ichiro Hayakawa,* Ryosuke Nagatani, Masaki Ikeda, Dong-eun Yoo, Keita Saito, Hideo Kigoshi, Akira Sakakura,* Org. Lett. 2019, 21 (16), 6337–6341.
DOI: 10.1021/acs.orglett.9b02232
74. "Toward the Synthesis of SB-203207: Construction of Four Contiguous Nitrogen-Containing Stereogenic Centers"
Ichiro Hayakawa,* Anna Nagayasu, Akira Sakakura,* J. Org. Chem. 2019, 84 (23), 15614–15623.
DOI: 10.1021/acs.joc.9b02627
75. "Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction"
Yuya Araki, Natsumi Miyoshi, Kazuki Morimoto, Takayuki Kudoh, Haruki Mizoguchi, Akira Sakakura,* J. Org. Chem. 2020, 85 (2), 798–805.
DOI: 10.1021/acs.joc.9b02811
76. "Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor"
Kana Shintani, Haruna Ebisu, Minagi Mukaiyama, Taisei Hatanaka, Takumi Chinen, Daisuke Takao, Yoko Nagumo, Akira Sakakura, Ichiro Hayakawa,* Takeo Usui,* ACS Med. Chem. Lett. 2020, 11 (6), 1125–1129.
DOI: 10.1021/acsmedchemlett.9b00526
77. "Enantioselective Diels–Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts"
Yudai Fujii, Ryota Nakao, Saki Sugihara, Keita Fujita, Yuya Araki, Takayuki Kudoh, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura,* Synlett, eFirst.
DOI: 10.1055/s-0040-1707302
78. "Kinetic Resolution of α-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester–Amide Exchange Reaction"
Ryota Nakao, Yudai Fujii, Ichiro Hayakawa, Haruki Mizoguchi, Akira Sakakura,* Synlett, eFirst.
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