2025

• A Landscape of Cancer Initiation and Cancer Stem Cells.
  

  Seno M.
  Cancers (Basel) 17(2):203, 2025 (published on Jan 9, 2025). doi: 10.3390/cancers17020203. PMID: 39857984; PMCID: PMC11764454.

2023

• Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ.
  

  Afify SM, Hassan G, Zahra MH, Nawara HM, Abu Quora HA, Osman A, Mansour H, Kumon K, Seno A, Chen L, Satoh A, Salomon DS, Seno M.
  Biomaterials. 301:122249, 2023 (published in Oct, 2023). doi: 10.1016/j.biomaterials.2023.122249. Epub 2023 Jul 20. PMID: 37506511; PMCID: PMC10530245.

• Methods in Cancer Stem Cell Biology.
  

  Afify SM, Seno M.
  1st ed. 2023. Singapore: Springer Nature Singapore : Imprint: Springer, 2023. ISBN978-981-99-1330-5.ISBN978-981-99-1331-2 (eBook). doi.org/10.1007/978-981-99-1331-2.

• GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation.
  

  Hassan G, Afify SM, Zahra MH, Nawara HM, Kumon K, Iwasaki Y, Salomon DS, Seno A, Seno M.
  Cytotechnology 75:243-253, 2023 (published on April 1, 2023). doi.org/10.1007/s10616-023-00575-1.

• Cancer Initiation and Inflammation.
  

  Afify, S.M., Seno, A., Hinuma, S., Seno M.
  In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. (Published 03 March 2023). ISBN978-3-030-80962-1. doi.org/10.1007/978-3-030-80962-1_34-1.

• Cancer Stem Cells Contribute to Drug Resistance in Multiple Different Ways.
  

  Zahra MH, Nawara HM, Hassan G, Afify SM, Seno A, Seno M.
  Adv Exp Med Biol. 1393:125-139, 2022 (published on Jan 2, 2023). doi: 10.1007/978-3-031-12974-2_6.

• Functional and Molecular Characters of Cancer Stem Cells Through Development to Establishment.
  

  Afify SM, Hassan G, Ishii H, Monzur S, Nawara HM, Osman A, Abu Quora HA, Sheta M, Zahra MH, Seno A, Seno M.
  Adv Exp Med Biol. 1393:83-101, 2022 (published on Jan 2, 2023). doi: 10.1007/978-3-031-12974-2_4.

• ERBB Signaling Pathway in Cancer Stem Cells.
  

  Hassan G, Seno M.
  Adv Exp Med Biol. 1393:65-81, 2022 (published on Jan 2, 2023). doi: 10.1007/978-3-031-12974-2_3.

• Up-regulation of Dsg2 confered stem cells with malignancy through wnt/β-catenin signaling pathway.
  

  Chen L, Liu Y, Xu Y, Afify SM, Gao A, Du J, Liu B, Fu X, Liu Y, Yan T, Zhu Z, Seno M.
  Exp Cell Res. 422(1):113416, 2023 Jan 1. doi: 10.1016/j.yexcr.2022.113416.

2022

• Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis.
  

  Minematsu H, Afify SM, Sugihara Y, Hassan G, Zahra MH, Seno A, Adachi M, Seno M.
  Sci Rep. 2022 Sep 17;12(1):15628. doi: 10.1038/s41598-022-19265-7.

• A comparative study of metastatic potentials of three different cancer stem cell models.
  

  Mansour, H, Afify, SM, Hassan, G., Abu Quora, HA, Nawara, HM, Zahra, MH, Du, J, Monzur, S, Ohara, T, Seno, A, Seno M.
  Advances in Cancer Biology - Metastasis, 5:100062, October 2022. ISSN 2667-3940.

• Optimization of production and characterization of a recombinant soluble human Cripto-1 protein inhibiting self-renewal of cancer stem cells.
  

  Afify SM, Hassan G, Nawara HM, H Zahra M, Xu Y, Alam MJ, Saitoh K, Mansour H, Abu Quora HA, Sheta M, Monzur S, Du J, Oh SY, Seno A, Salomon DS, Seno M.
  J Cell Biochem. 123:1183-1196, 2022 May 16. doi: 10.1002/jcb.30272.

• Cancer-inducing niche: the force of chronic inflammation.
  

  Afify SM, Hassan G, Seno A, Seno M.
  Br J Cancer. 127(2):193-201, 2022 Jul. doi: 10.1038/s41416-022-01775-w.

• Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells.
  

  Monzur S, Hassan G, Afify SM, Kumon K, Mansour H, Nawara HM, Sheta M, Abu Quora HA, Zahra MH, Xu Y, Fu X, Seno A, Wikström P, Szekeres FLM, Seno M.
  Cell Biochem Funct. 40(3):310-320, 2022 Apr. doi: 10.1002/cbf.3696.

• The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.
  

  Hassan G, Zahra MH, Seno A, Seno M.
  Sci Rep. 12(1):2711, 2022 Feb 17. doi: 10.1038/s41598-022-04980-y.

• Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.
  

  Xu Y, Afify SM, Du J, Liu B, Hassan G, Wang Q, Li H, Liu Y, Fu X, Zhu Z, Chen L, Seno M.
  J Exp Clin Cancer Res. 41(1):29, 2022 Jan 21. doi: 10.1186/s13046-021-02167-3.

• The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells.
  

  Xu Y, Afify SM, Du J, Liu B, Hassan G, Wang Q, Li H, Liu Y, Fu X, Zhu Z, Chen L, Seno M.
  Sci Rep. 12(1):347, 2022 Jan 10. doi: 10.1038/s41598-021-04265-w.

• Cancer Stem Cell Initiation by Tumor-Derived Extracellular Vesicles.
  

  Afify SM, Hassan G, Yan T, Seno A, Seno M.
  Methods Mol Biol. 2549:399-407, 2022. doi: 10.1007/7651_2021_371.

2021

• Chapter 12 - Induced pluripotent stem cells as the source of cancer stem cells providing novel concepts of cancer: gaps between in vitro and in vivo in induced pluripotent stem cells modeling.
  

  Akimasa Seno, Said M. Afify, Ghmkin Hassan, Masaharu Seno.
  In “iPSC Derived Progenitors (Ed. Alexander Birbrair)”, Advances in Stem Cell Biology, Vol.13, pp265-288, 2022, Academic Press, 1st Edition - Nov 10, 2021. ISBN 9780323855457.

• Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2.
  

  Kumon K, Afify SM, Hassan G, Ueno S, Monzur S, Nawara HM, Quora HAA, Sheta M, Xu Y, Fu X, Zahra MH, Seno A, Seno M.
  Sci Rep. 11(1):23977, 2021 Dec 14. doi: 10.1038/s41598-021-03298-5.

• Availability of Pluripotent Stem Cells from Normal Cells in Cancer Science.
  

  Ghmkin Hassan, Said M. Afify, Juan Du, Akimasa Seno, Masaharu Seno.
  In “Stem Cells Latest Advances, Ed. Khawaja H. Haider”, 2021, Springer e-book, ISBN: 978-3-030-77052-5, Springer; 1st ed. 2021 edition (December 2, 2021).

• MEK1/2 is a bottleneck that induces cancer stem cells to activate the PI3K/AKT pathway.
  

  Hassan G, Afify SM, Du J, Nawara HM, Sheta M, Monzur S, Zahra MH, Abu Quora HA, Mansour H, El-Ghlban S, Uesaki R, Seno A, Seno M.
  Biochem Biophys Res Commun. 583:49-55, 2021 Oct 23. doi: 10.1016/j.bbrc.2021.10.047.

• Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis.
  

  Sheta M, Hassan G, Afify SM, Monzur S, Kumon K, Abu Quora HA, Farahat M, Zahra MH, Fu X, Seno A, Seno M.
  Cancer Lett. 521:142-154, 2021 Aug 26. doi: 10.1016/j.canlet.2021.08.026.

• Metformin suppresses self-renewal and stemness of cancer stem cell models derived from pluripotent stem cells.
  

  Zahra MH, Afify SM, Hassan G, Nawara HM, Kumon K, Seno A, Seno M.
  Cell Biochem Funct. 39(7):896-907, 2021 Oct. doi: 10.1002/cbf.3661.

• Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells.
  

  Abu Quora HA, Zahra MH, El-Ghlban S, Nair N, Afify SM, Hassan G, Nawara HM, Sheta M, Monzur S, Fu X, Osman A, Seno A, Seno M.
  Am J Cancer Res. 15;11(7):3475-3495, 2021 Jul. PMCID: PMC8332865.

• Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy.
  

  Ishii H, Afify SM, Hassan G, Salomon DS, Seno M.
  Cancers (Basel). 13(10):2491, 2021 May 20. doi: 10.3390/cancers13102491.

• Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy.
  

  Nawara HM, Afify SM, Hassan G, Zahra MH, Atallah MN, Seno A, Seno M.
  Biomedicines. 9(5):500, 2021 May 2. doi: 10.3390/biomedicines9050500.

• How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer.
  

  Nawara HM, Afify SM, Hassan G, Zahra MH, Atallah MN, Seno A, Seno M.
  Expert Rev Anticancer Ther. 21(6):605-619. 2021 Jun. doi: 10.1080/14737140.2021.1918001.

• An assay for cancer stem cell-induced angiogenesis on chick chorioallantoic membrane.
  

  Nawara HM, Afify SM, Hassan G, Zahra MH, Atallah MN, Seno A, Seno M.
  Cell Biol Int. 2021 Apr;45(4):749-756. doi: 10.1002/cbin.11511.

• A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth.
  

  Ishii H, Zahra MH, Takayanagi A, Seno M.
  Int J Mol Sci. 22(4):1709, 2021 Feb 8. doi: 10.3390/ijms22041709.

• Isolation and characterization of cancer stem cells derived from human glioblastoma.
  

  Ishii H, Mimura Y, Zahra MH, Katayama S, Hassan G, Afify SM, Seno M.
  Am J Cancer Res. 11(2):441-457, 2021 Feb 1. PMCID: PMC7868757.

• Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro.
  

  Ghmkin Hassan G, Afify SM. Kitano S, Seno A, Ishii H, Shang Y, Matsusaki M, Seno M.
  Processes,9(1): 45, 2021. https:// doi.org/10.3390/pr9010045.

2020

• Tumor-associated macrophages derived from cancer stem cells.
  

  Osman A, Oze M, Afify SM, Hassan G, El-Ghlban S, Nawara HM, Fu X, Zahra MH, Seno A, Winer I, Salomon DS, Seno M.
  Acta Histochem. 122(8):151628, 2020 Sep 26. doi: 10.1016/j.acthis.2020.151628.

• Metastasis Model of Cancer Stem Cell-Derived Tumors.
  

  Mansour H, Hassan G, Afify SM, Yan T, Seno A, Seno M.
  Methods Protoc. 3(3):E60. 2020 Aug 21. doi: 10.3390/mps3030060.

• Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment.
  

  Du J, Xu Y, Sasada S, Oo AKK, Hassan G, Mahmud H, Khayrani AC, Alam MJ, Kumon K, Uesaki R, Afify SM, Mansour HM, Nair N, Zahra MH, Seno A, Okada N, Chen L, Yan T, Seno M.
  Sci Rep. 10(1):9955. 2020 Jun 22. doi: 10.1038/s41598-020-66471-2.

• Paclitaxel and Sorafenib: the effective combination of suppressing the self-renewal of cancer stem cells.
  

  Nawara HM, Afify SM, Hassan G, Zahra MZ, Atallah MN, Mansour H, Abu Quora HA, Alam MJ, Osman A, Kakuta H, Hamada H, Seno A, Seno M.
  Cancers (Basel). 12(6):1360, 2020. doi: 10.3390/cancers12061360.

• Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments.
  

  Hassan G, Seno M.
  Cells, 9(5):1293, 2020. DOI: 10.3390/cells9051293.

• Cancer stem cell generation by silenced MAPK enhancing PI3K/AKT signaling.
  

  Hassan G, Du J, Afify SM, Seno A, Seno M.
  Med Hypotheses.141:109742, 2020 Apr15. doi: 10.1016/j.mehy.2020.109742.

• Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs.
  

  Osman A, Afify SM, Hassan G, Fu X, Seno A, Seno M.
  Cancers (Basel). 2020 Apr 4;12(4). pii: E879, 2020 Apr 4. doi: 10.3390/cancers12040879.

• A novel model of liver cancer stem cells developed from induced pluripotent stem cells.
  

  Afify SM, Sanchez Calle A, Hassan G, Kumon K, Nawara HM, Zahra MH, Mansour HM, Khayrani AC, Alam MJ, Du J, Seno A, Iwasaki Y, Seno M.
  Br J Cancer. ;122(9):1378-1390, 2020 Apr.doi: 10.1038/s41416-020-0792-z.

• Upregulated Ccl20 and Ccr6 in cancer stem cells converted from mouse iPS cells.
  

  Du J, Seno A, Sasada S, Xu Y, Oo AKK, Hassan G, Ueno S, Afify SM, Zahra MH, Okada N, Chen L, Fu X, Tokutaka H, Yan T, Seno M.
  J Res Med Dent Sci.,8(1): 200-207, 2020.

2019

• Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells.
  

  Hassan G, Afify SM, Nair N, Kumon K, Osman A, Du J, Mansour H, Abu Quora HA, Nawara HM, Satoh A, Zahra MH, Okada N, Seno A, Seno M.
  Cancers (Basel),12(1).pii: E82, 2019. Dec 29:10.3390/cancers12010082.

• Cancer Stem Cell Induction from mouse Embryonic Stem Cell.
  

  Seno A, Murakami C, EI-Aarag B, Iwasaki Y, Ohara T, Seno M.
  Oncology Letters,18: 2756-2762, 2019. doi: 10.3892/ol.2019.10614.

• Daunorubicin can eliminate iPS-derived Cancer Stem Cells via ICAD/CAD-Independent DNA Fragmentation.
  

  Seno A, Mizutani A, Aizawa K, Onoue R, Masuda J, Ochi N, Taniguchi S, Sota T, Hiramoto Y, Michiue T, Nair N, Seno M.
  Cancer Drug Resist 2019;2:335-350. doi: 10.20517/cdr.2019.01.

• Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation.
  

  Afify SM, Seno M.
  Cancers(Basel). 2019 Mar 11;11(3). pii: E345. doi: 10.3390/cancers11030345. Review.
  PMID:30862050; PMCID:PMC6468812.

• Targeting Ovarian Cancer Cells Overexpressing CD44 with Immunoliposomes Encapsulating Glycosylated Paclitaxel.
  

  Khayrani AC, Mahmud H, Oo AKK, Zahra MH, Oze M, Du J, Alam MJ, Afify SM, Quora HAA,
  Shigehiro T, Calle AS, Okada N, Seno A, Fujita K, Hamada H, Seno Y, Mandai T, Seno M.
  Int J Mol Sci. 2019 Feb 27;20(5). pii: E1042. doi: 10.3390/ijms20051042.
  PMID:30818864; PMCID:PMC6429518.

• A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness.
  

  Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, Sato H, Komoto S, Narusaka T, Tomono Y, Xing B, Chen Y, Tazawa H, Kagawa S, Shirakawa Y, Kasai T, Seno M, Matsukawa A, Fujiwara T.
  Cancers(Basel). 2019 Feb 3;11(2). pii: E177. doi: 10.3390/cancers11020177.
  PMID:30717462; PMCID:PMC6406536.

• Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells.
  

  Kunoh T, Shimura T, Kasai T, Matsumoto S, Mahmud H, Khayrani AC, Seno M, Kunoh H, Takada J.
  Nanotechnology. 2019 Feb 1;30(5):055101. doi: 10.1088/1361-6528/aaedd5. Epub 2018 Nov 30.
  PMID:30499457.

• Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells.

  Hassan G, Afify SM, Nair N, Kumon K, Osman A, Du J, Mansour H, Abu Quora HA, Nawara HM, Satoh A, Zahra MH, Okada N, Seno A, Seno M.
  Cancers(Basel). 2019 Dec 29;12(1). pii: E82. doi: 10.3390/cancers1210082. PubMed
  PMID:31905766.

2018

• Exogenous Cripto-1 Suppresses Self-Renewal of Cancer Stem Cell Model.
  

  Alam MJ, Takahashi R, Afify SM, Oo AKK, Kumon K, Nawara HM, Khayrani AC, Du J, Zahra MH, Seno A, Salomon DS, Seno M.
  Int J Mol Sci.2018 Oct 26;19(11). pii:E3345. doi: 10.3390/ijms 19113345.
  PMID:30373174; PMCID:PMC6274844.

• Five Fibrosis Biomarkers Together with Serum Ferritin Level to Diagnose Liver Fibrosis and Cirrhosis.
  

  Afify SM, Tabll A, Nawara HM, EI Kassas M, Elfert A, Seno M, EI-Kousy S.
  Clin Lab.2018 Oct 1;64(10):1685-1693. doi 10.7754/Clin.Lab.2018.180502.
  PMID:30336529.

• Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.
  

  Masuda J, Takayama E, Ichinohe T, Strober W, Mizuno-Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss I, Kawamoto H, Seno A, Vaidyanath A, Umemura N, Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N, Seno M.
  Exp Ther Med. 2018 Nov;16(5):4277-4282. doi: 10.3892/etm.2018.6689.
  Epub 2018 Sep 4.
  PMID:30344701; PMCID:PMC6176164

• HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells.
  

  Ono K, Eguchi T, Sogawa C, Calderwood SK, Futagawa J, Kasai T, Seno M, Okamoto K, Sasaki A, Kozaki KI.
  J Cell Biochem.2018 Sep;119(9):7350-7362. doi: 10.1002/jcb.27039.
  Epub 2018 May 16.
  PMID:29768689

• Cytokine Expression and Macrophage Localization in Xenograft and Alloraft Tumor Models Stimulated with Lipopolysaccharide.
  

  Masuda J, Shigehiro T, Matsumoto T, Satoh A, Mizutani A, Umemura C, Saito S, Kijihira M, Takayama E, Seno A, Murakami H, Seno M.
  Int J Mol Sci. 2018 Apr 23;19(4). pii: E1261. doi: 10.3390/ijms 19041261.
  PMID:29690614

• Up-Regulation of PI 3-Kinases and the Activation of PI3K-Akt Signaling Pathway in Cancer Stem-Like Cells Through DNA Hypomethylation Mediated by the Cancer Microenvironment.
  

  Oo AKK, Calle AS, Nair N, Mahmud H, Vaidyanath A, Yamauchi J, Khayrani AC, Du J, Alam MJ, Seno A, Mizutani A, Murakami H, Iwasaki Y, Chen L, Kasai T, Seno M.
  Transl Oncol. 2018 Apr 2;11(3):653-663. doi: 10.1016/j.tranon.2018.03.001
  Epub 2018 Apr 2.
  PMID:29621663

• Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein.
  

  Mahmud H, Kasai T, Khayrani AC, Asakura M, Oo AKK, Du J, Vaidyanath A, EI-Ghlban S, Mizutani A, Seno A, Murakami H, Masuda J, Seno M.
  Int J Mol Sci. 2018 Feb 26;19(3). pii: E659. doi: 10.3390/ijms 19030659.
  PMID:29495404

2017

• Iron depletion is a novel therapeutic strategy to target cancer stem cells.
  

  Ninomiya T, Ohara T, Noma K, Katsura Y, Katsube R, Kashima H, Tomono Y, Tazawa H, Kagawa S, Shirakawa Y, Kimura F, Chen L, Kasai T, Seno M, Matsukawa A, Fujiwara T.
  Oncotarget. 2017 Oct 12;8(58):98405-98416. doi: 10.18632/oncotarget.21846.
  eCollection 2017 Nov 17.
  PMCID:PMC5716739

• Practical Liposomal Formulation for Taxanes with Polythoxylated Castor Oil and Ethanol with Complete Encapsulation Efficiency and High Loading Efficiency.
  

  Shigehiro T, Masuda J, Saito S, Khayrani AC, Jinno K, Seno A, Vaidyanath A, Mizutani A, Kasai T, Murakami H, Satoh A, Ito T, Hamada H, Seno Y, Mandai T, Seno M.
  Nanomaterials (Basel). 2017 Sep 23;7(10). pii: E290. doi: 10.3390/nano7100290.
  PMID:28946623

• A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment.
  

  Nair N, Challe AS, Zahra MH, Oo AK, Preito-Villa M, Hurley L, Vaidyanath A, Seno A, Masuda J, Iwasaki Y, Tanaka H, Kasai T, Seno M.
  Sci Rep.2017 Jul 28;7(1):6838. doi;10.1038/s41598-017-07144-5.
  PMID:28754894

• DDS先端技術の製剤への応用開発
  5章　がんをターゲットしたDDS技術の開発と製剤応用
  　　第1節　腫瘍を標的とした抗体提示リポソームの開発と製剤化
  

  妹尾　昌治，重廣　司.
  技術情報協会発刊, 2017.6.30, pp.249-262.

• Immunoliposomes: Recent Progress of Liposomal Drug Delivery system Coupled with Antibodies.
  in "Liposomes: Historical, Clinical and Molecular Perspectives (Eds. Benjamin R. Pearson)" Nova Publishers, New York, Pub.

  Shigehiro T, Seno M.

2016

• A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).
  

  Calle AS, Nair N, Oo AK, Prieto-Vila M, Koga M, Khayrani AC, Hussein M, Hurley L, Vaidyanath A, Seno A, Iwasaki Y, Calle M, Kasai T, Seno M.
  AM J Cancer Res.2016 Dec 1;6(12):2799-2815. eCollection 2016.
  PMID:28042501

• Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2.
  

  El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M.
  Biomed pharmacother.2017 Jan;85:549-555. doi:10.1016/j.biopha.2016.11.063. Epub 2016 Nov 23.
  PMID:27889230

• Synthesis,Biological Evaluation,Docking and QSAR Studies of Some Novel Naphthalimide Dithiocarbamate Analogs as Antitumor and Anti-Inflammatory Agents.

  Zahra MH, Osman AMA, Agwa H, Nair N, Calle AS, Hurley L, Farag D, Kasai T, Seno M, Zahran M.
  Med Chem(Los Angeles) 2016,6(12):694-703. doi: 10.4172/2161-0444.1000417

• iPSC-derived cancer stem cells provide a model of tumor vasculature.
  

  Prieto-Vila M, Yan T, Calle AS, Nair N, Hurley L, Kasai Y, Kakuta H, Masuda J, Murakami H, Mizutani A, Seno M.
  Am J Cancer Res.2016 Sep 1;6(9):1906-1921.
  PMID:27725898

• Characterization of Gene Expression Patterns among Artificially Developed Cancer Stem Cells Using Spherical Self-Organizing Map.
  

  Seno A(equal contributor), Kasai T(equal contributor), Ikeda M, Vaidyanath A, Masuda J, Mizutani A, Murakami H, Ishikawa T, Seno M.
  Cancer Inform.2016 Aug 16;15:163-78. doi:10.4137/CIN.S39839.
  PMID:27559294

• Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting.
  

  Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M.
  Appl Biochem Biotechnol.2016 Jul 12.
  PMID:27406037

• Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content.
  

  Miyake H, Oda T, Katsuta O, Seno M, Nakamura M.
  Invest Ophthalmol Vis Sci.2016 Jun 1;57(7):3268-75. doi:10.1167/iovs.16-19227.
  PMID:26966393

• A Unique Procedure to Identify Cell Surface Markers Through a Spherical Self-Organizing Map Applied to DNA Microarray Analysis.
  

  Sugii Y(equal contributor), Kasai T(equal contributor), Ikeda M, Vaidyanath A, Kumon K, Mizutani A, Seno A, Tokutaka H, Kudoh T, Seno M.
  Biomark Cancer.2016 Mar 3;8:17-23. doi:10.4137/BIC S33542.
  PMID:26966393

• Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient.
  

  Shigehiro T, Zhai W, Vaidyanath A, Masuda J, Mizutani A, Kasai T, Murakami H, Hamada H, Salomon DS, Mikuni K, Seno Y, Mandai T, Seno M.
  J Microencapsul.2016;33(2):172-82. doi:10.3109/02652048.2016.1144815
  PMID:26885749

2015

• Spherical Self-Organizing Map Detects MYBL 1 As Candidate Gene for Triple-Negative Breast Cancer

  Ikeda M, Kumon K, Omoto K, Sugii Y, Mizutani A, Vaidyanath A, Kudoh T, Kasai T, Masuda S, Seno M.
  Neurosci Biomed Eng,3(2):94-101.

• Insight into Cancer Stem Cell Niche; Lessons from Cancer Stem Cell Models Generated In Vitro.

  Mizutani A, Yan T, Vaidyanath A, Masuda J, Seno A, Kasai T, Murakami H, Seno M.
  Biology in Stem Cell Niche,Part of the Series Cell Biology and Regenerative Medicine,pp.211-226.

• Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3β under Oxidative Stress.
  

  Ishii H, Kamikawa S, Hirohata S, Mizutani A, Abe K, Seno M, Oohashi T, Ninomiya Y.
  Acta Med Okayama.2015;69(3):145-53.
  PMID:26101190

2014

• Bacteria: prospective savior in battle against cancer.
  

  Nair N, Kasai T, Seno M.
  Anticancer Res.2014 Nov;34(11):6289-96. Review.

• Efficient drug delivery of Paclitaxel glycoside: a novel solubility gradientencapsulation into liposomes coupled with immunoliposomes preparation.
  

  Shigehiro T (equal contributor) , Kasai T (equal contributor) , Murakami M, Sekhar SC, Tominaga Y, Okada M, Kudoh T, Mizutani A, Murakami H, Salomon DS, Mikuni K, Mandai T, Hamada H, Seno M.
  PLoS One.2014 Sep 29;9(9):e107976. doi: 10.1371/journal.pone.0107976. eCollection 2014.
  PMID:25264848

• Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles.
  

  Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.
  J Cancer. 2014 Jul 5;5(7):572-84. doi: 10.7150/jca.8865. eCollection 2014.
  PMID:25057308

• In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs.
  

  El-Aarag BY, Kasai T, Zahran MA, Zakhary NI, Shigehiro T, Sekhar SC, Agwa HS, Mizutani A, Murakami H, Kakuta H, Seno M.
  Int Immunopharmacol. 2014 May 21;21(2):283-292. doi: 10.1016/j.intimp.2014.05.007.
  PMID:24859059

• Chlorotoxin-Fc Fusion Inhibits Release of MMP-2 from Pancreatic Cancer Cells.
  

  El-Ghlban S, Kasai T, Shigehiro T, Yin HX, Sekhar S, Ida M, Sanchez A, Mizutani A, Kudoh T, Murakami H, Seno M.
  Biomed Res Int. 2014;2014:152659. doi: 10.1155/2014/152659. Epub 2014 Jan 6.
  PMID:24511528

• Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells.
  

  Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, El-Aarag BY, Liu Y, Kudoh T, Salomon DS, Fu L, Seno M.
  Am J Cancer Res. 2014 Jan 15;4(1):80-8. eCollection 2014.
  PMID:24482741

2013

• Cancer stem cells maintain a hierarchy of differentiation by creating their niche.
  

  Matsuda S, Yan T, Mizutani A, Sota T, Hiramoto Y, Prieto-Vila M, Chen L, Satoh A, Kudoh T, Kasai T, Murakami H, Fu L, Salomon DS, Seno M.
  Int J Cancer. 2013 Dec 3. doi: 10.1002/ijc.28648.
  PMID:24323788

• Theranostic Protein Targeting ErbB2 for Bioluminescence Imaging and Therapy for Cancer.
  

  Han XJ, Sun LF, Nishiyama Y, Feng B, Michiue H, Seno M, Matsui H, Tomizawa K.
  PLoS One. 2013 Sep 17;8(9):e75288. doi: 10.1371/journal.pone.0075288.
  PMID:24069396

• Steering target selectivity and potency by fragment-based de novo drug design.
  

  Rodrigues T, Kudoh T, Roudnicky F, Lim YF, Lin YC, Koch CP, Seno M, Detmar M, Schneider G.
  Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10006-9. doi: 10.1002/anie.201304847. Epub 2013 Aug 26.
  PMID:24030898

• Development of an epidermal growth factor derivative with EGFR blocking activity.
  

  Panosa C, Tebar F, Ferrer-Batalle M, Fonge H, Seno M, Reilly RM, Massaguer A, De Llorens R.
  PLoS One. 2013 Jul 30;8(7):e69325. doi: 10.1371/journal.pone.0069325. Print 2013.
  PMID:23935985

• Identification of caveolin-1 as a potential causative factor in the generation of trastuzumab resistance in breast cancer cells.
  

  Sekhar SC, Kasai T, Satoh A, Shigehiro T, Mizutani A, Murakami H, El-Aarag BY, Salomon DS, Massaguer A, de Llorens R, Seno M.
  J Cancer. 2013 Jun 21;4(5):391-401. doi: 10.7150/jca.6470. Print 2013.
  PMID:23833684

• Nano-micrometer-architectural acidic silica prepared from iron oxide of Leptothrix ochracea origin.
  

  Hashimoto H, Itadani A, Kudoh T, Fukui S, Kuroda Y, Seno M, Kusano Y, Ikeda Y, Benino Y, Nanba T, Nakanishi M, Fujii T, Takada J.
  ACS Appl Mater Interfaces. 2013 Jun 12;5(11):5194-200. doi: 10.1021/am401029r. Epub 2013 May 23.
  PMID:23673436

• Acidic amorphous silica prepared from iron oxide of bacterial origin.
  

  Hashimoto H, Itadani A, Kudoh T, Kuroda Y, Seno M, Kusano Y, Ikeda Y, Nakanishi M, Fujii T, Takada J.
  ACS Appl Mater Interfaces. 2013 Feb 13;5(3):518-23. doi: 10.1021/am302837p. Epub 2013 Feb 4.
  PMID: 23331569

• Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
  

  Jin G, Mizutani A, Fukuda T, Otani T, Yan T, Prieto Vila M, Murakami H, Kudoh T, Hirohata S, Kasai T, Salomon DS, Seno M.
  Mol Biol Rep. 2013 Apr;40(4):3165-71. doi: 10.1007/s11033-012-2390-5. Epub 2012 Dec 28.
  PMID: 23271121

• Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.
  

  Nagaoka T, Karasawa H, Turbyville T, Rangel MC, Castro NP, Gonzales M, Baker A, Seno M, Lockett S, Greer YE, Rubin JS, Salomon DS, Bianco C.
  Cell Signal. 2013 Jan;25(1):178-89. doi: 10.1016/j.cellsig.2012.09.024. Epub 2012 Sep 27.
  PMID: 23022962

2012

• Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis.
  

  Kasai T, Nakamura K, Vaidyanath A, Chen L, Sekhar S, El-Ghlban S, Okada M, Mizutani A, Kudoh T, Murakami H, Seno M.
  J Drug Deliv. 2012;2012:975763. doi: 10.1155/2012/975763. Epub 2012 Dec 5.
  PMID: 23304519

• Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.
  

  Jin G, Mizutani A, Fukuda T, Chen L, Nakanishi K, Yan T, Kudoh T, Hirohata S, Kasai T, Murakami H, Salomon DS, Seno M.
  Growth Factors. 2012 Oct;30(5):344-55. Epub 2012 Jul 31.
  PMID:22845717

• Electroporation and use of hepatitis B virus envelope L proteins as bionanocapsules.
  

  Yamada T, Jung J, Seno M, Kondo A, Ueda M, Tanizawa K, Kuroda S.
  Cold Spring Harb Protoc.2012 Jun 1;2012(6):702-5. doi:10.1101/pdb.prot069534.
  PMID: 22661433

• The conformational polymorphism of the green fluorescent protein.
  

  Tan H, Li Y, Chen L, Kudoh T, Kasai T, Seno M.
  Mol Biol (Mosk). 2012 Jan-Feb;46(1):156-61.
  PMID: 22642113

• A model of cancer stem cells derived from mouse induced pluripotent stem cells.
  

  Chen L, Kasai T, Li Y, Sugii Y, Jin G, Okada M, Vaidyanath A, Mizutani A, Satoh A, Kudoh T, Hendrix MJ, Salomon DS, Fu L, Seno M.
  PLoS One. 2012;7(4):e33544. doi: 10.1371/journal.pone.0033544.
  Epub 2012 Apr 12
  PMID: 22511923

2011

• Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand.

  A.Vaidyanath, T.Hashizume, T.Nagaoka, N.Takeyashu, H.Satoh, L.Chen, J.Wang, T.Kasai, T.Kudoh, A.Satoh, L.Fu, M.Seno.
  J.Cell Mol Med vol.15, no.11, pp.2525-2538. doi: 10.1111/j.1582-4934.2011.01277.x.
  PMID: 21323863

• Exploring the mechanism for biological evolution: DNA methyltransferase is the pushing power of DNA and protein evolution

  Tan H and Seno M.
  Lambert Academic Publishing, 2011, ISBN 978-3-8443-1725-1.

• Clustering Genes, Tissues, Cells and Bioactive Chemicals by Sphere SOM
  in: Self Organizing Maps- Applications and Novel Algorithm Design.

  Yuh Sugii, Takayuki Kudoh, Takayuki Otani, Masashi Ikeda, Heizo Tokutaka and Masaharu Seno.
  Cahpter 20, pp 371-386; InTech Janeza Trdine 9, 51000 Rijeka, Croatia, Jan. 2011.

• Construction of a high-efficiency multi-site-directed mutagenesis

  H.Tan, Y.Li, L.Chen, T.Kasai, M.Seno.
  African J. Biotech Vol.10, no.3, pp.449-452

• Extracellular matrix modulates insulin production during differentiation of AR42J cells: functional role of Pax6 transcription factor.
  

  Hamamoto K, Yamada S, Hara A, Kodera T, Seno M, Kojima I.
  J Cell Biochem. 2011 Jan; 112(1):318-29. doi: 10.1002/jcb.22930.
  PMID:21069736

2010

• Optimization of Bacterial Plasmid Transformation Using Nanomaterials Based on the Yoshida Effect

  Tan H, Fu L, Seno M.
  Int J Mol Sci. 2010 Dec 3;11(12):4962-4972. doi: 10.3390/ijms11124962. Epub 2010 Dec 3.
  PMID:21614185

• First Report of Cucumber mosaic virus in Sweet Cherry in the People's Republic of China

  Tan H, Li S, Du X, Seno M.
  Plant Disease. 2010 Nov;94(11):1378. doi: 10.1094/PDIS-07-10-0549

• E-selectin targeting to visualize tumors in vivo.

  Hirai M, Hiramatsu Y, Iwashita S, Otani T, Chen L, Li YG, Okada M, Oie K, Igarashi K, Wakita H, Seno M.
  Contrast Media Mol Imaging. 2010 Mar;5(2):70-77. doi: 10.1002/cmmi.367.
  PMID: 20235150

• Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells.

  Hirai M, Minematsu H, Hiramatsu Y, Kitagawa H, Otani T, Iwashita S, Kudoh T, Chen L, Li Y, Okada M, Salomon DS, Igarashi K, Chikuma M, Seno M.
  Int J Pharm. 2010 May 31;391(1-2):274-283. doi: 10.1016/j.ijpharm.2010.02.030. Epub 2010 Mar 6.
  PMID: 20211714

• Production of biologically active IgG hinge-tag soluble epidermal growth factor receptors (ErbB).

  Otani T, Hashizume T, Nagaoka T, Fukuda T, Tang CK, Salomon DS, Seno M.
  Biotechnol Lett. 2010 Mar;32(3):361-366. doi: 10.1007/s10529-009-0160-9. Epub 2009 Nov 7.
  PMID: 19898750

2009

• Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats.

  Kodera T, Yamada S, Yamamoto Y, Hara A, Tanaka Y, Seno M, Umezawa K, Takei I, Kojima I.
  Endocr J. 2009 Dec;56(6):799-806. Epub 2009 Jun 24.
  PMID: 19550075

• Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes.

  Fukuda T, Iwata M, Kitazoe M, Maeda T, Salomon D, Hirohata S, Tanizawa K, Kuroda S, Seno M.
  Growth Factors. 2009 Aug;27(4):228-36. doi: 10.1080/08977190902987149.
  PMID: 19521893

• Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His.

  Feng B, Tomizawa K, Michiue H, Miyatake S, Han XJ, Fujimura A, Seno M, Kirihata M, Matsui H.
  Biomaterials. 2009 Mar;30(9):1746-55. doi: 10.1016/j.biomaterials.2008.12.010.
  Epub 2009 Jan 1.
  PMID: 19121537

2008

• 「自己組織化マップとそのツール」（大北正昭、徳高平蔵、藤村喜久郎、植田英功 編）
  第７章４節 球面SOMを用いてガン細胞表面のマーカーを特定する（pp.127-136）

  妹尾昌治、杉井裕、拓亜、アボウ・シャリエハ　サマー、徳高平蔵
  シュプリンガー・ジャパン、２００８年１２月１０日発行

• Spherical self-organizing map as a helpful tool to identify category-specific cell surface markers.

  Tuoya, Sugii Y, Satoh H, Yu D, Matsuura Y, Tokutaka H, Seno M.
  Biochem Biophys Res Commun. 2008 Nov 14;376(2):414-8. doi: 10.1016/j.bbrc.2008.09.010.
  Epub 2008 Sep 13.
  PMID: 18793609

• Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300

  Hirota M, Watanabe K, Hamada S, Sun Y, Strizzi L, Mancino M, Nagaoka T, Gonzales M, Seno M, Bianco C, Salomon DS.
  Cell Signal. 2008 Sep;20(9):1632-41. doi: 10.1016/j.cellsig.2008.05.003. Epub 2008 May 18.
  PMID: 18595660

• Intracellular delivery of glutathione S-transferase-fused proteins into mammalian cells by polyethylenimine-glutathione conjugates.

  Murata H, Futami J, Kitazoe M, Yonehara T, Nakanishi H, Kosaka M, Tada H, Sakaguchi M, Yagi Y, Seno M, Huh NH, Yamada H.
  J Biochem. 2008 Oct;144(4):447-55. doi: 10.1093/jb/mvn087. Epub 2008 Jul 4.
  PMID: 18603589

• Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice.

  Yamamoto Y, Yamada S, Kodera T, Hara A, Motoyoshi K, Tanaka Y, Nagaoka T, Seno M, Kojima I.
  Growth Factors. 2008 Aug;26(4):173-9. doi: 10.1080/08977190802136854.
  PMID: 19378417

• A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1.

  Nagaoka T, Fukuda T, Hashizume T, Nishiyama T, Tada H, Yamada H, Salomon DS, Yamada S, Kojima I, Seno M.
  J Mol Biol. 2008 Jun 27;380(1):83-94. doi: 10.1016/j.jmb.2008.03.054. Epub 2008 Apr 3.
  PMID: 18508082

• A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4.

  Hisanaga E, Park KY, Yamada S, Hashimoto H, Takeuchi T, Mori M, Seno M, Umezawa K, Takei I, Kojima I.
  Endocr J. 2008 Jul;55(3):535-543. Epub 2008 May 15.
  PMID: 18480554

• Cell type dependent endocytic internalization of ErbB2 with an artificial peptide ligand that binds to ErbB2

  Hashizume T, Fukuda T, Nagaoka T, Tada H, Yamada H, Watanabe K, Salomon DS, Seno M.
  Cell Biol Int. 2008 Jul;32(7):814-826. doi: 10.1016/j.cellbi.2008.03.012. Epub 2008 Mar 29.
  PMID: 18442934

• Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.

  Murata H, Futami J, Kitazoe M, Kosaka M, Tada H, Seno M, Yamada H.
  J Biosci Bioeng. 2008 Jan;105(1):34-38. doi: 10.1263/jbb.105.34.
  PMID: 18295717

• Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation

  Bokui N, Otani T, Igarashi K, Kaku J, Oda M, Nagaoka T, Seno M, Tatematsu K, Okajima T, Matsuzaki T, Ting K, Tanizawa K, Kuroda S.
  FEBS Lett. 2008 Jan 23;582(2):365-71. Epub 2007 Dec 17.
  PMID: 18082140

2007

• Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

  Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS.
  J Biol Chem. 2007 Oct 26;282(43):31643-55. Epub 2007 Aug 24.
  PMID: 17720976

• Development of bionanocapsules targeting brain tumors

  Tsutsui Y, Tomizawa K, Nagita M, Michiue H, Nishiki T, Ohmori I, Seno M, Matsui H.
  J Control Release. 2007 Sep 26;122(2):159-164. Epub 2007 Jun 27.
  PMID: 17692421

• 「自己組織化マップとその応用」（徳高平蔵、大北正昭、藤村喜久郎編）
  第９章SOMを用いたガン細胞識別法

  妹尾昌治、松浦弥三郎、拓亜、徳高平蔵、大北正昭
  J Control Release. 2007 Sep 26;122(2):159-164. Epub 2007 Jun 27.
  PMID: 17692421

• 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines

  Yamada H, Tamada T, Kosaka M, Miyata K, Fujiki S, Tano M, Moriya M, Yamanishi M, Honjo E, Tada H, Ino T, Yamaguchi H, Futami J, Seno M, Nomoto T, Hirata T, Yoshimura M, Kuroki R.
  Protein Sci. 2007 Jul;16(7):1389-1397.
  PMID: 17586772

• Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

  Nagaoka T, Fukuda T, Yoshida S, Nishimura H, Yu D, Kuroda S, Tanizawa K, Kondo A, Ueda M, Yamada H, Tada H, Seno M.
  J Control Release. 2007 Apr 23;118(3):348-356. Epub 2006 Dec 28.
  PMID: 17306405

• Characteristics of hollow microtubes consisting of amorphous iron oxide nanoparticles produced by iron oxidizing bacteria, Leptothrix ochracea

  Hashimoto H, Yokoyama S, Asaoka H, Kusano Y, Ikeda Y, Seno M, TakadaJ, Fujii T, Nakanishi M and Murakami R.
  Journal of Magnetism and Magnetic Materials Volume 310, Issue 2, Part 3, March 2007, Pages 2405-2407

• Conophylline and Betacellulin-delta4: an Effective Combination of Differentiation Factors for Pancreatic beta Cells

  Kitamura RI, Ogata T, Tanaka Y, Motoyoshi K, Seno M, Takei I, Umezawa K, Kojima I.
  Endocr J. 2007 May;54(2):255-264. Epub 2007 Feb 16.
  PMID: 17303930

• 「バイオナノキャリアの開発とがん遺伝子治療への応用」

  近藤昭彦、黒田俊一、谷澤克行、妹尾昌治、上田政和
  バイオテクノロジージャーナル, vol.7, no.1, pp. 41-47, 2007.1

• Gene therapy of liver tumors with human liver-specific nanoparticles

  Iwasaki Y, Ueda M, Yamada T, Kondo A, Seno M, Tanizawa K, Kuroda S, Sakamoto M, Kitajima M.
  Cancer Gene Ther. 2007 Jan;14(1):74-81. Epub 2006 Sep 22.
  PMID: 16990844

2006

• Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties

  Yagi H, Ueda M, Jinno H, Aiura K, Mikami S, Tada H, Seno M, Yamada H, Kitajima M.
  Cancer Sci. 2006 Dec;97(12):1315-1320. Epub 2006 Oct 9.
  PMID: 17032310

• Secretory production system of bionanocapsules using a stably transfected insect cell line

  Shishido T, Muraoka M, Ueda M, Seno M, Tanizawa K, Kuroda S, Fukuda H, Kondo A.
  Appl Microbiol Biotechnol. 2006 Dec;73(3):505-511. Epub 2006 Jul 18.
  PMID: 16847600

• 「中空バイオナノ粒子を用いたDDSの開発とその産業化」

  近藤昭彦、黒田俊一、谷澤克行、妹尾昌治、上田政和
  Drug Delivery System, vol.21, no.4, pp. 435-443, 2006.7

• Denatured and Reversibly Cationized p53 Readily Enters Cells and Simultaneously Folds to the Functional Protein in the Cells

  Murata H, Sakaguchi M, Futami J, Kitazoe M, Maeda T, Doura H, Kosaka M, Tada, H, Seno M, Huh NH, Yamada H.
  Biochemistry. 2006 May 16;45(19):6124-6132.
  PMID: 16681385

• Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding

  Sanderson MP, Abbott CA, Tada H, Seno M, Dempsey PJ, Dunbar AJ.
  J Cell Biochem. 2006 Oct 1;99(2):609-623.
  PMID: 16676357

• Mechanisms of the growth-inhibitory effect of the RNase-EGF fused protein against EGFR-overexpressing cells

  Hoshimoto S, Ueda M, Jinno H, Kitajima M, Futami J, Seno M.
  Anticancer Res. 2006 Mar-Apr;26(2A):857-63.
  PMID: 16619480

• Engineered bio-nanocapsules, the selective vector for drug delivery system

  Yu D, Fukuda T, Tuoya, Kuroda S, Tanizawa K, Kondo A, Ueda M, Yamada T, Tada H, Seno M.
  IUBMB Life. 2006 Jan;58(1):1-6. Review.
  PMID: 16596748

2005

• Differentiation of adult hepatic stem-like cells into pancreatic endocrine cells

  Yamada S, Terada K, Ueno Y, Sugiyama T, Seno M, Kojima I.
  Cell Transplant. 2005;14(9):647-653.

• Betacellulin-delta4, a novel differentiation factor for pancreatic beta-cells, ameliorates glucose intolerance in streptozotocin-treated rats

  Ogata T, Dunbar AJ, Yamamoto Y, Tanaka Y, Seno M, Kojima I.
  Endocrinology. 2005 Nov;146(11):4673-4681.

• Identification of cell surface marker candidates on SV-T2 cells using DNA microarray on DLC-coated glass

  Tuoya, Hirayama K, Nagaoka T, Yu D, Fukuda T, Tada H, Yamada H, Seno M.
  Biochem Biophys Res Commun. 2005 Aug 19;334(1):263-268.

• The specific delivery of proteins to human liver cells by engineered bio-nanocapsules

  Yu D, Amano C, Fukuda T, Yamada T, Kuroda S, Tanizawa K, Kondo A, Ueda M, Yamada H, Tada H, Seno M.
  FEBS J. 2005 Jul;272(14):3651-3660.

• Protein transduction assisted by polyethylenimine-cationized carrier proteins

  Kitazoe M, Murata H, Futami J, Maeda T, Sakaguchi M, Miyazaki M, Kosaka M, Tada H, Seno M, Huh NH, Namba M, Nishikawa M, Maeda Y, Yamada H.
  J Biochem (Tokyo). 2005 Jun;137(6):693-701.

• Anti-angiogenic effect of an insertional fusion protein of human basic fibroblast growth factor and ribonuclease-1

  Hayashida T, Ueda M, Aiura K, Tada H, Onizuka M, Seno M, Yamada H, Kitajima M.
  Protein Eng Des Sel. 2005 Jul;18(7):321-327. Epub 2005 Jun 24.

• 「革新的なナノキャリア：中空バイオナノ粒子によるピンポイントDDS」

  近藤昭彦、黒田俊一、谷澤克行、妹尾昌治、上田政和
  バイオインダストリー５月号, vol.22, no.5, pp.22-27, 2005.5.

• 「中空バイオナノ粒子を用いたピンポイントDDSの開発」

  近藤昭彦、黒田俊一、谷澤克行、妹尾昌治、上田政和
  Chemical Engineering, vol.50, no.5, pp.351-356, 2005.5

• Intracellular delivery of proteins into mammalian living cells by polyethyleneimine-cationization

  Futami J, Kitazoe M, Maeda T, Nukui E, Sakaguchi M, Kosaka J, Miyazaki M, Kosaka M, H Tada, Seno M, Sasaki J, Hhuh N, Namba M, Yamada H.
  J Biosci Bioeng. 2005 Feb; 99(2):95-103.

2004

• 「中空バイオナノ粒子が拓く新しい医療技術」

  黒田俊一、山田忠範、妹尾昌治、近藤昭彦、上田政和、谷澤克行
  化学工業, vol.55, no.12, pp.936-942, 2004.12

• 「中空バイオナノ粒子を用いたピンポイントドラッグデリバリーシステム」

  山田忠範、妹尾昌治、近藤昭彦、上田政和、谷澤克行、黒田俊一
  高分子論文集、Japanese Jouranal of Polymer Science and Technology Vol.61, No.12, 606-612, 2004

• Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice

  Strizzi L, Bianco C, Normanno N, Seno M, Wechselberger C, Wallace-Jones B, Khan NI, Hirota M, Sun Y, Sanicola M, Salomon DS.
  J Cell Physiol. 2004 Nov;201(2):266-276.

• Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells

  Ogata T, Park KY, Seno M, Kojima I.
  Endocr J. 2004 Jun;51(3):381-386.

• Insertional-fusion of basic fibroblast growth factor endowed ribonuclease1 with enhanced cytotoxicity by steric blockade of inhibitor interaction

  Tada H, Onizuka M, Muraki K, Masuzawa W, Futami J, Kosaka M, Seno M, Yamada H.
  FEBS Lett. 2004 Jun 18;568(1-3):39-43.

• Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles

  Yamada T, Ueda M, Seno M, Kondo A, Tanizawa K, Kuroda S.
  Curr Drug Targets Infect Disord. 2004 Jun;4(2):163-167. [Review]

• Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats

  Li L, Yi Z, Seno M, Kojima I.
  Diabetes. 2004 Mar; 53(3):608-615.

2003

• 「中空バイオナノ粒子によるピンポイントドラッグデリバリーシステム」

  近藤昭彦、黒田俊一、谷澤克行、妹尾昌治、上田政和
  化学工学　 (2003) 67巻12号 649-714頁、化学工学会発行

• 「ナノパーティクル・テクノロジー」（細川益男監修、野城 清編著）
  4.2.6 タンパク質中空ナノ粒子, 123-127頁
  6.3 タンパク質中空ナノ粒子のドラッグデリバリーシステムへの応用, 171-178頁

  妹尾昌治、黒田俊一、近藤昭彦、谷澤克行、上田政和
  2003年11月、日刊工業新聞社（東京）発行

• 「中空バイオナノ粒子を用いるピンポイントDDSおよび遺伝子導入法」

  黒田俊一、近藤昭彦、妹尾昌治、谷澤克行、上田政和
  ナノバイオテクノロジー最前線、植田充美監修、
  2003年10月、シーエムシー出版（東京）発行

• Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice

  Li L, Seno M, Yamada H, Kojima I.
  Am J Physiol Endocrinol Metab. 2003 Sep; 285(3): E577-E583.

• Nanoparticles for the delivery of genes and drugs to human hepatocytes

  Yamada T, Iwasaki Y, Tada H, Iwabuki H, Chuah MK, VandenDriessche T, Fukuda H, Kondo A, Ueda M, Seno M, Tanizawa K, Kuroda S.
  Nat Biotechnol. 2003 Aug; 21(8):885-890.

• 「バイオナノ粒子を用いる遺伝子・薬剤のピンポイントドラッグデリバリーシステム」

  妹尾昌治、黒田俊一、近藤昭彦、多田宏子、谷澤克行、上田政和
  バイオインダストリー４月号、20(4):54-64

• 「先端医療技術とバイオベンチャー」

  妹尾昌治
  ハイテクインフォメーション　No.144,２月号p.18-31
  

このページの先頭へ